WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 576501
Description: ICI-222155 is an aldose reductase inhibitor.
MedKoo Cat#: 576501
Chemical Formula: C9H12N2O4S
Exact Mass: 244.0518
Molecular Weight: 244.26
Elemental Analysis: C, 44.25; H, 4.95; N, 11.47; O, 26.20; S, 13.13
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: ICI 222155; ICI222155; ICI-222155
IUPAC/Chemical Name: 4-Amino-2,6-dimethylphenylsulfonyl nitromethane
InChi Key: FIMPGOJEDMNMHL-UHFFFAOYSA-N
InChi Code: InChI=1S/C9H12N2O4S/c1-6-3-8(10)4-7(2)9(6)16(14,15)5-11(12)13/h3-4H,5,10H2,1-2H3
SMILES Code: Cc1cc(N)cc(C)c1S(=O)(=O)C[N+](=O)[O-]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 244.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1. Cunha JM, Jolivalt CG, Ramos KM, Gregory JA, Calcutt NA, Mizisin AP. Elevated lipid peroxidation and DNA oxidation in nerve from diabetic rats: effects of aldose reductase inhibition, insulin, and neurotrophic factors. Metabolism. 2008 Jul;57(7):873-81. doi: 10.1016/j.metabol.2008.01.021. PMID: 18555826; PMCID: PMC2518323.
2. Calcutt NA, Li L, Yaksh TL, Malmberg AB. Different effects of two aldose reductase inhibitors on nociception and prostaglandin E. Eur J Pharmacol. 1995 Oct 16;285(2):189-97. doi: 10.1016/0014-2999(95)00402-7. PMID: 8566138.