WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 576499
Description: ICI-170777 is a vasodilator with positive inotropic effects
MedKoo Cat#: 576499
Chemical Formula: C9H9N3OS
Exact Mass: 207.0466
Molecular Weight: 207.25
Elemental Analysis: C, 52.16; H, 4.38; N, 20.28; O, 7.72; S, 15.47
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: ICI 170777; ICI170777; ICI-170777
IUPAC/Chemical Name: 2H-1,3,4-Thiadiazin-2-one, 3,6-dihydro-6-methyl-5-(4-pyridinyl)-, (+-)-
InChi Key: PXZLHVGFLSUUIW-UHFFFAOYSA-N
InChi Code: InChI=1S/C9H9N3OS/c1-6-8(11-12-9(13)14-6)7-2-4-10-5-3-7/h2-6H,1H3,(H,12,13)
SMILES Code: CC1SC(=O)NN=C1c2ccncc2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 207.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1. Collis MG, Keddie JR, Rouse W. The cardiovascular pharmacology of ICI 170777 ((6RS)-6-methyl-5-(pyrid-4-yl)-3H,6H-1,3,4- thiadiazin-2-one) a novel compound with positive inotropic and vasodilator effects. Br J Pharmacol. 1989 Jun;97(2):409-18. doi: 10.1111/j.1476-5381.1989.tb11968.x. PMID: 2758224; PMCID: PMC1854538.
2. McKillop D, Pickup KJ. Different inhibition and induction profiles of hepatic drug metabolism in rats and dogs by two structurally related pyridyl diazinone cardiotonic agents. Biochem Pharmacol. 1991 Feb 1;41(3):411-7. doi: 10.1016/0006-2952(91)90538-g. PMID: 1994899.