WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 576493
Description: ICI-190622 HCl is an anticonvulsant and anxiolytic.
MedKoo Cat#: 576493
Name: ICI-190622 HCl
Chemical Formula: C15H18ClN5O
Exact Mass: 319.12
Molecular Weight: 319.79
Elemental Analysis: C, 56.34; H, 5.67; Cl, 11.09; N, 21.90; O, 5.00
This product is not in stock, which may be available by custom synthesis.
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Synonym: ICI-190622 hydrochloride; ICI-190622 HCl; ICI190622 HCl; ICI 190622 HCl
IUPAC/Chemical Name: 1H-Pyrazolo(3,4-b)pyridine-5-carboxamide, 4-amino-1-(3-pentynyl)-N-2-propenyl-, monohydrochloride
InChi Key: TUEMLOZMUNWHLM-UHFFFAOYSA-N
InChi Code: 1S/C15H17N5O.ClH/c1-3-5-6-8-20-14-11(10-19-20)13(16)12(9-18-14)15(21)17-7-4-2;/h4,9-10H,2,6-8H2,1H3,(H2,16,18)(H,17,21);1H
SMILES Code: Cl.CC#CCCn1ncc2c(N)c(cnc12)C(=O)NCC=C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 319.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1. Patel JB, Meiners BA, Salama AI, Malick JB, U'Prichard DC, Giles RE, Goldberg ME, Bare TM. Preclinical studies with pyrazolopyridine non-benzodiazepine anxiolytics: ICI 190,622. Pharmacol Biochem Behav. 1988 Apr;29(4):775-9. doi: 10.1016/0091-3057(88)90205-5. PMID: 2901116.
2. Bare TM, McLaren CD, Campbell JB, Firor JW, Resch JF, Walters CP, Salama AI, Meiners BA, Patel JB. Synthesis and structure-activity relationships of a series of anxioselective pyrazolopyridine ester and amide anxiolytic agents. J Med Chem. 1989 Dec;32(12):2561-73. doi: 10.1021/jm00132a011. PMID: 2573731.