ICI-190622 HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 576493

CAS#: 103586-13-6

Description: ICI-190622 HCl is an anticonvulsant and anxiolytic.

Chemical Structure

ICI-190622 HCl
CAS# 103586-13-6

Theoretical Analysis

MedKoo Cat#: 576493
Name: ICI-190622 HCl
CAS#: 103586-13-6
Chemical Formula: C15H18ClN5O
Exact Mass: 319.12
Molecular Weight: 319.79
Elemental Analysis: C, 56.34; H, 5.67; Cl, 11.09; N, 21.90; O, 5.00

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: ICI-190622 hydrochloride; ICI-190622 HCl; ICI190622 HCl; ICI 190622 HCl

IUPAC/Chemical Name: 1H-Pyrazolo(3,4-b)pyridine-5-carboxamide, 4-amino-1-(3-pentynyl)-N-2-propenyl-, monohydrochloride


InChi Code: 1S/C15H17N5O.ClH/c1-3-5-6-8-20-14-11(10-19-20)13(16)12(9-18-14)15(21)17-7-4-2;/h4,9-10H,2,6-8H2,1H3,(H2,16,18)(H,17,21);1H

SMILES Code: Cl.CC#CCCn1ncc2c(N)c(cnc12)C(=O)NCC=C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 319.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Patel JB, Meiners BA, Salama AI, Malick JB, U'Prichard DC, Giles RE, Goldberg ME, Bare TM. Preclinical studies with pyrazolopyridine non-benzodiazepine anxiolytics: ICI 190,622. Pharmacol Biochem Behav. 1988 Apr;29(4):775-9. doi: 10.1016/0091-3057(88)90205-5. PMID: 2901116.

2. Bare TM, McLaren CD, Campbell JB, Firor JW, Resch JF, Walters CP, Salama AI, Meiners BA, Patel JB. Synthesis and structure-activity relationships of a series of anxioselective pyrazolopyridine ester and amide anxiolytic agents. J Med Chem. 1989 Dec;32(12):2561-73. doi: 10.1021/jm00132a011. PMID: 2573731.