WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 576490
Description: ICI-118233 is a selective inhibitor of dense-vesicle cyclic AMP phosphodiesterase in liver tissue.
MedKoo Cat#: 576490
Chemical Formula: C12H12N4O2
Exact Mass: 244.096
Molecular Weight: 244.25
Elemental Analysis: C, 59.01; H, 4.95; N, 22.94; O, 13.10
This product is not in stock, which may be available by custom synthesis.
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Synonym: ICI 118233; ICI118233; ICI-118233
IUPAC/Chemical Name: Urea, N-(4-(1,6-dihydro-6-oxo-3-pyridazinyl)phenyl)-N'-methyl-
InChi Key: FKWJRHATWBHIRH-UHFFFAOYSA-N
InChi Code: InChI=1S/C12H12N4O2/c1-13-12(18)14-9-4-2-8(3-5-9)10-6-7-11(17)16-15-10/h2-7H,1H3,(H,16,17)(H2,13,14,18)
SMILES Code: CNC(=O)Nc1ccc(cc1)C2=NNC(=O)C=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 244.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1. Pyne NJ, Anderson N, Lavan BE, Milligan G, Nimmo HG, Houslay MD. Specific antibodies and the selective inhibitor ICI 118233 demonstrate that the hormonally stimulated 'dense-vesicle' and peripheral-plasma-membrane cyclic AMP phosphodiesterases display distinct tissue distributions in the rat. Biochem J. 1987 Dec 15;248(3):897-901. doi: 10.1042/bj2480897. PMID: 2829845; PMCID: PMC1148634.