WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 576489
Description: ICI-180080 is a thromboxane antagonist.
MedKoo Cat#: 576489
Chemical Formula: C19H26O5
Exact Mass: 334.178
Molecular Weight: 334.41
Elemental Analysis: C, 68.24; H, 7.84; O, 23.92
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Synonym: ICI 180080; ICI180080; ICI-180080
IUPAC/Chemical Name: 5-Heptenoic acid, 7-(4-(2-hydroxyphenyl)-2,2-dimethyl-1,3-dioxan-5-yl)-, (4alpha,5alpha(Z))-
InChi Key: VTLAMBSAMRROPW-HUAIYETOSA-N
InChi Code: InChI=1S/C19H26O5/c1-19(2)23-13-14(9-5-3-4-6-12-17(21)22)18(24-19)15-10-7-8-11-16(15)20/h3,5,7-8,10-11,14,18,20H,4,6,9,12-13H2,1-2H3,(H,21,22)/b5-3-/t14-,18+/m1/s1
SMILES Code: CC1(C)OC[C@@H](C\C=C/CCCC(=O)O)[C@H](O1)c2ccccc2O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 334.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1. Jessup CL, Jessup R, Wayne M. Pharmacological actions of ICI 180080, a novel thromboxane receptor antagonist. J Pharm Pharmacol. 1986 Oct;38(10):754-7. doi: 10.1111/j.2042-7158.1986.tb04484.x. PMID: 2878996.
2. Brown GR, Foubister AJ. ICI 180080, a novel selective thromboxane receptor antagonist: synthesis and relative activity. J Pharm Pharmacol. 1986 Sep;38(9):706-8. doi: 10.1111/j.2042-7158.1986.tb03117.x. PMID: 2877076.