WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 576488
CAS#: 86015-39-6
Description: ICI-147798 HCl is a beta adrenoceptor antagonist.
MedKoo Cat#: 576488
Name: ICI-147798 HCl
CAS#: 86015-39-6
Chemical Formula: C24H31Cl2N7O4
Exact Mass: 551.1815
Molecular Weight: 552.46
Elemental Analysis: C, 52.18; H, 5.66; Cl, 12.83; N, 17.75; O, 11.58
This product is not in stock, which may be available by custom synthesis.
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Synonym: ICI-147798 hydrochloride; ICI-147798 HCl; ICI 147798 HCl; ICI147798 HCl
IUPAC/Chemical Name: 3,5-Diamino-6-chloro-N-(2-((2-((2-hydroxy-3-(1-naphthalenyloxy)propyl)amino)ethyl)amino)-1,1-dimethyl-2-oxoethyl)-2-pyrazinecarboxamide hydrochloride
InChi Key: FPYKIVKAYUQLGA-UHFFFAOYSA-N
InChi Code: InChI=1S/C24H30ClN7O4.ClH/c1-24(2,32-22(34)18-20(26)31-21(27)19(25)30-18)23(35)29-11-10-28-12-15(33)13-36-17-9-5-7-14-6-3-4-8-16(14)17;/h3-9,15,28,33H,10-13H2,1-2H3,(H,29,35)(H,32,34)(H4,26,27,31);1H
SMILES Code: Cl.CC(C)(NC(=O)c1nc(Cl)c(N)nc1N)C(=O)NCCNCC(O)COc2cccc3ccccc23
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 552.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1. Keith RA, Hwang TF, Murthy VS, Kau ST, Salama AI, Giles RE. ICI 147,798: a slowly dissociable beta adrenoceptor antagonist that causes insurmountable beta-1 and surmountable beta-2 adrenoceptor antagonism in isolated tissues. J Pharmacol Exp Ther. 1989 Jan;248(1):240-8. PMID: 2563288.
