WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 576485

CAS#: 83812-65-1

Description: ICI-147798 is a beta adrenoceptor antagonist.

Chemical Structure

CAS# 83812-65-1

Theoretical Analysis

MedKoo Cat#: 576485
Name: ICI-147798
CAS#: 83812-65-1
Chemical Formula: C24H30ClN7O4
Exact Mass: 515.2048
Molecular Weight: 516.0
Elemental Analysis: C, 55.87; H, 5.86; Cl, 6.87; N, 19.00; O, 12.40

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: ICI147798; ICI 147798; ICI-147798

IUPAC/Chemical Name: Pyrazinecarboxamide, 3,5-diamino-6-chloro-N-(2-((2-((2-hydroxy-3-(1-naphthalenyloxy)propyl)amino)ethyl)amino)-1,1-dimethyl-2-oxoethyl)-


InChi Code: InChI=1S/C24H30ClN7O4/c1-24(2,32-22(34)18-20(26)31-21(27)19(25)30-18)23(35)29-11-10-28-12-15(33)13-36-17-9-5-7-14-6-3-4-8-16(14)17/h3-9,15,28,33H,10-13H2,1-2H3,(H,29,35)(H,32,34)(H4,26,27,31)

SMILES Code: CC(C)(NC(=O)c1nc(Cl)c(N)nc1N)C(=O)NCCNCC(O)COc2cccc3ccccc23

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 516.0 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Doggrell SA, Surman AJ. Loss of maximum attenuation and receptor reserve for isoprenaline at the beta 2-adrenoceptors of the portal veins of hypertensive rats. J Hypertens. 1995 Sep;13(9):1023-9. doi: 10.1097/00004872-199509000-00013. PMID: 8586820.

2. Keith RA, Hwang TF, Murthy VS, Kau ST, Salama AI, Giles RE. ICI 147,798: a slowly dissociable beta adrenoceptor antagonist that causes insurmountable beta-1 and surmountable beta-2 adrenoceptor antagonism in isolated tissues. J Pharmacol Exp Ther. 1989 Jan;248(1):240-8. PMID: 2563288.

3. Kau ST, Howe BB, Li JH, Smith LH, Keddie JR, Barlow JJ, Giles RE, Goldberg ME. ICI 147,798: a novel diuretic agent with beta adrenoceptor blocking activity. J Pharmacol Exp Ther. 1987 Sep;242(3):818-26. PMID: 2888873.