WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 576473

CAS#: 67249-51-8

Description: ICI-106270 is a potent anti-hypertensive agent with similar mechanism of action to clonidine.

Chemical Structure

CAS# 67249-51-8

Theoretical Analysis

MedKoo Cat#: 576473
Name: ICI-106270
CAS#: 67249-51-8
Chemical Formula: C12H12ClFN2
Exact Mass: 238.0673
Molecular Weight: 238.69
Elemental Analysis: C, 60.38; H, 5.07; Cl, 14.85; F, 7.96; N, 11.74

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: ICI 106270; ICI106270; ICI-106270

IUPAC/Chemical Name: 3H-Pyrrolo(1,2-a)imidazole, 6-(2-chloro-6-fluorophenyl)-2,5,6,7-tetrahydro-


InChi Code: InChI=1S/C12H12ClFN2/c13-9-2-1-3-10(14)12(9)8-6-11-15-4-5-16(11)7-8/h1-3,8H,4-7H2

SMILES Code: Fc1cccc(Cl)c1C2CN3CCN=C3C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 238.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Ruffolo RR Jr, Yaden EL, Timmermans PB, van Zwieten PA, Hynes MD. Characterization of the alpha adrenoceptor-mediated effects and antihypertensive activity of ICI 106270: comparison with clonidine. J Pharmacol Exp Ther. 1984 Apr;229(1):58-66. PMID: 6323690.

2. Clough DP, Hatton R, Pettinger SJ. A new centrally acting antihypertensive (ICI 106270) which separates antihypertensive effects from sedation. Arzneimittelforschung. 1981;31(10):1698-703. PMID: 7198445.