Ibuprofen arginine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 576462

CAS#: 57469-82-6

Description: Ibuprofen arginine is a nonsteroidal anti-inflammatory drug (NSAID) used for treating pain, fever, and inflammation.

Chemical Structure

Ibuprofen arginine
CAS# 57469-82-6

Theoretical Analysis

MedKoo Cat#: 576462
Name: Ibuprofen arginine
CAS#: 57469-82-6
Chemical Formula: C19H32N4O4
Exact Mass: 380.2424
Molecular Weight: 380.49
Elemental Analysis: C, 59.98; H, 8.48; N, 14.73; O, 16.82

Price and Availability

Size Price Availability Quantity
5.0mg USD 250.0 2 Weeks
25.0mg USD 565.0 2 Weeks
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Synonym: Dolo-spedifen; Ibuprofen arginate; Ibuprofen arginine; Spedifen

IUPAC/Chemical Name: L-Arginine, alpha-methyl-4-(2-methylpropyl)benzeneacetate (1:1)


InChi Code: InChI=1S/C13H18O2.C6H14N4O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15;7-4(5(11)12)2-1-3-10-6(8)9/h4-7,9-10H,8H2,1-3H3,(H,14,15);4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t;4-/m.0/s1

SMILES Code: CC(C)Cc1ccc(cc1)C(C)C(=O)[O-].N[C@@H](CCCNC(=N)[NH3+])C(=O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 380.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Moore RA, Derry S, Wiffen PJ, Straube S, Aldington DJ. Overview review: Comparative efficacy of oral ibuprofen and paracetamol (acetaminophen) across acute and chronic pain conditions. Eur J Pain. 2015 Oct;19(9):1213-23. doi: 10.1002/ejp.649. Epub 2014 Dec 22. Review. PubMed PMID: 25530283.

2: Derry S, Wiffen PJ, Moore RA. Single dose oral ibuprofen plus caffeine for acute postoperative pain in adults. Cochrane Database Syst Rev. 2015 Jul 14;7:CD011509. doi: 10.1002/14651858.CD011509.pub2. Review. PubMed PMID: 26171993.

3: Ohlsson A, Walia R, Shah SS. Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants. Cochrane Database Syst Rev. 2015 Feb 18;2:CD003481. doi: 10.1002/14651858.CD003481.pub6. Review. PubMed PMID: 25692606.

4: Koh W, Nguyen KP, Jahr JS. Intravenous non-opioid analgesia for peri- and postoperative pain management: a scientific review of intravenous acetaminophen and ibuprofen. Korean J Anesthesiol. 2015 Feb;68(1):3-12. doi: 10.4097/kjae.2015.68.1.3. Epub 2015 Jan 28. Review. PubMed PMID: 25664148; PubMed Central PMCID: PMC4318862.

5: Kelly LE, Sommer DD, Ramakrishna J, Hoffbauer S, Arbab-Tafti S, Reid D, Maclean J, Koren G. Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics. 2015 Feb;135(2):307-13. doi: 10.1542/peds.2014-1906. PubMed PMID: 25624387.