Conoidin A

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555967

CAS#: 18080-67-6

Description: Conoidin A inactivates peroxiredoxins by covalently binding to the catalytic cysteine on the enzyme.

Chemical Structure

Conoidin A
CAS# 18080-67-6

Theoretical Analysis

MedKoo Cat#: 555967
Name: Conoidin A
CAS#: 18080-67-6
Chemical Formula: C10H8Br2N2O2
Exact Mass: 345.8953
Molecular Weight: 347.994
Elemental Analysis: C, 34.51; H, 2.32; Br, 45.92; N, 8.05; O, 9.19

Price and Availability

Size Price Availability Quantity
100.0mg USD 350.0 2 Weeks
200.0mg USD 550.0 2 Weeks
500.0mg USD 1250.0 2 Weeks
1.0g USD 2250.0 2 Weeks
2.0g USD 4250.0 2 Weeks
5.0g USD 6450.0 2 Weeks
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Synonym: Conoidin A

IUPAC/Chemical Name: 2,3-bis(bromomethyl)-quinoxaline 1,4-dioxide


InChi Code: InChI=1S/C10H8Br2N2O2/c11-5-9-10(6-12)14(16)8-4-2-1-3-7(8)13(9)15/h1-4H,5-6H2

SMILES Code: BrCC1=C(CBr)[N+]([O-])=C2C=CC=CC2=[N+]1[O-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 347.994 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Jang YJ, Kim JS, Yun PR, Seo YW, Lee TH, Park JI, Chun SY. Involvement of peroxiredoxin 2 in cumulus expansion and oocyte maturation in mice. Reprod Fertil Dev. 2020 May;32(8):783-791. doi: 10.1071/RD19310. PMID: 32389179.

2: Stancill JS, Happ JT, Broniowska KA, Hogg N, Corbett JA. Peroxiredoxin 1 plays a primary role in protecting pancreatic β-cells from hydrogen peroxide and peroxynitrite. Am J Physiol Regul Integr Comp Physiol. 2020 May 1;318(5):R1004-R1013. doi: 10.1152/ajpregu.00011.2020. Epub 2020 Apr 15. PMID: 32292063; PMCID: PMC7272767.

3: Tan X, Chen J, Keep RF, Xi G, Hua Y. Prx2 (Peroxiredoxin 2) as a Cause of Hydrocephalus After Intraventricular Hemorrhage. Stroke. 2020 May;51(5):1578-1586. doi: 10.1161/STROKEAHA.119.028672. Epub 2020 Apr 13. PMID: 32279622; PMCID: PMC7192237.

4: Olson KR, Briggs A, Devireddy M, Xian M, Gao Y. Are the beneficial effects of 'antioxidant' lipoic acid mediated through metabolism of reactive sulfur species? Free Radic Biol Med. 2020 Jan;146:139-149. doi: 10.1016/j.freeradbiomed.2019.10.410. Epub 2019 Oct 30. PMID: 31676393.

5: Feng T, Zhao R, Sun F, Lu Q, Wang X, Hu J, Wang S, Gao L, Zhou Q, Xiong X, Dong X, Wang L, Han B. TXNDC9 regulates oxidative stress-induced androgen receptor signaling to promote prostate cancer progression. Oncogene. 2020 Jan;39(2):356-367. doi: 10.1038/s41388-019-0991-3. Epub 2019 Sep 2. PMID: 31477836.

6: Bian L, Zhang J, Wang M, Keep RF, Xi G, Hua Y. Intracerebral Hemorrhage- Induced Brain Injury in Rats: the Role of Extracellular Peroxiredoxin 2. Transl Stroke Res. 2020 Apr;11(2):288-295. doi: 10.1007/s12975-019-00714-x. Epub 2019 Jul 4. Erratum in: Transl Stroke Res. 2019 Aug 9;: PMID: 31273681; PMCID: PMC6942235.

7: Lee TH, Jin JO, Yu KJ, Kim HS, Lee PC. Inhibition of peroxiredoxin 2 suppresses Wnt/β-catenin signaling in gastric cancer. Biochem Biophys Res Commun. 2019 Apr 30;512(2):250-255. doi: 10.1016/j.bbrc.2019.03.039. Epub 2019 Mar 15. PMID: 30879771.

8: Olson KR, Gao Y. Effects of inhibiting antioxidant pathways on cellular hydrogen sulfide and polysulfide metabolism. Free Radic Biol Med. 2019 May 1;135:1-14. doi: 10.1016/j.freeradbiomed.2019.02.011. Epub 2019 Feb 19. PMID: 30790656.

9: Tam KC, Ali E, Hua J, Chataway T, Barritt GJ. Evidence for the interaction of peroxiredoxin-4 with the store-operated calcium channel activator STIM1 in liver cells. Cell Calcium. 2018 Sep;74:14-28. doi: 10.1016/j.ceca.2018.05.002. Epub 2018 May 15. PMID: 29804005.

10: Ryu DY, Kim KU, Kwon WS, Rahman MS, Khatun A, Pang MG. Peroxiredoxin activity is a major landmark of male fertility. Sci Rep. 2017 Dec 7;7(1):17174. doi: 10.1038/s41598-017-17488-7. PMID: 29215052; PMCID: PMC5719347.

11: Jeon HJ, Park YS, Cho DH, Kim JS, Kim E, Chae HZ, Chun SY, Oh JS. Peroxiredoxins are required for spindle assembly, chromosome organization, and polarization in mouse oocytes. Biochem Biophys Res Commun. 2017 Jul 22;489(2):193-199. doi: 10.1016/j.bbrc.2017.05.127. Epub 2017 May 25. PMID: 28552528.

12: Tilley LD, Krishnamurthy S, Westwood NJ, Ward GE. Identification of TgCBAP, a novel cytoskeletal protein that localizes to three distinct subcompartments of the Toxoplasma gondii pellicle. PLoS One. 2014 Jun 2;9(6):e98492. doi: 10.1371/journal.pone.0098492. PMID: 24887026; PMCID: PMC4041824.

13: Brizuela M, Huang HM, Smith C, Burgio G, Foote SJ, McMorran BJ. Treatment of erythrocytes with the 2-cys peroxiredoxin inhibitor, Conoidin A, prevents the growth of Plasmodium falciparum and enhances parasite sensitivity to chloroquine. PLoS One. 2014 Apr 3;9(4):e92411. doi: 10.1371/journal.pone.0092411. PMID: 24699133; PMCID: PMC3974718.

14: Nguyen JB, Pool CD, Wong CY, Treger RS, Williams DL, Cappello M, Lea WA, Simeonov A, Vermeire JJ, Modis Y. Peroxiredoxin-1 from the human hookworm Ancylostoma ceylanicum forms a stable oxidized decamer and is covalently inhibited by conoidin A. Chem Biol. 2013 Aug 22;20(8):991-1001. doi: 10.1016/j.chembiol.2013.06.011. Epub 2013 Jul 25. PMID: 23891152; PMCID: PMC3755041.

15: Liu G, Botting CH, Evans KM, Walton JA, Xu G, Slawin AM, Westwood NJ. Optimisation of conoidin A, a peroxiredoxin inhibitor. ChemMedChem. 2010 Jan;5(1):41-5. doi: 10.1002/cmdc.200900391. PMID: 19946931.

16: Haraldsen JD, Liu G, Botting CH, Walton JG, Storm J, Phalen TJ, Kwok LY, Soldati-Favre D, Heintz NH, Müller S, Westwood NJ, Ward GE. IDENTIFICATION OF CONOIDIN A AS A COVALENT INHIBITOR OF PEROXIREDOXIN II. Org Biomol Chem. 2009;7:3040-3048. doi: 10.1039/B901735F. PMID: 21359112; PMCID: PMC3043594.

Conoidin A

100.0mg / USD 350.0