WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 555965
Description: ML266, also known as CID-4694321, is activator of glucocerebrosidase (GCase). ML266 can serve as starting points to develop a novel approach towards small molecule treatment for patients suffering from Gaucher disease.
MedKoo Cat#: 555965
Chemical Formula: C24H22BrN3O4
Exact Mass: 495.0794
Molecular Weight: 496.361
Elemental Analysis: C, 58.08; H, 4.47; Br, 16.10; N, 8.47; O, 12.89
Synonym: CID-46943215; CID 46943215; CID46943215; ML266; ML 266; ML-266
IUPAC/Chemical Name: 2-(2-((4-Bromophenyl)amino)-2-oxoethoxy)-N-(2-(methyl(phenyl)amino)-2-oxoethyl)benzamide
InChi Key: VAPWBKACLHRZBZ-UHFFFAOYSA-N
InChi Code: InChI=1S/C24H22BrN3O4/c1-28(19-7-3-2-4-8-19)23(30)15-26-24(31)20-9-5-6-10-21(20)32-16-22(29)27-18-13-11-17(25)12-14-18/h2-14H,15-16H2,1H3,(H,26,31)(H,27,29)
SMILES Code: CN(C1=CC=CC=C1)C(CNC(C2=CC=CC=C2OCC(NC3=CC=C(C=C3)Br)=O)=O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 496.361 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
Rogers S, Patnaik S, Schoenen F, Zheng W, Choi J, Motabar O, Southall N, Westbroek W, Goldin E, Sidransky E, Leister W, Marugan JJ, Aubé J. Discovery, SAR, and Biological Evaluation of Non-inhibitory Chaperones of Glucocerebrosidase. 2012 Mar 27 [updated 2013 Mar 7]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. PMID: 23762943.