ML266
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MedKoo CAT#: 555965

CAS#: 1462267-08-8

Description: ML266, also known as CID-4694321, is activator of glucocerebrosidase (GCase). ML266 can serve as starting points to develop a novel approach towards small molecule treatment for patients suffering from Gaucher disease.


Chemical Structure

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ML266
CAS# 1462267-08-8

Theoretical Analysis

MedKoo Cat#: 555965
Name: ML266
CAS#: 1462267-08-8
Chemical Formula: C24H22BrN3O4
Exact Mass: 495.0794
Molecular Weight: 496.361
Elemental Analysis: C, 58.08; H, 4.47; Br, 16.10; N, 8.47; O, 12.89

Price and Availability

Size Price Availability Quantity
50.0mg USD 550.0 2 Weeks
100.0mg USD 950.0 2 Weeks
200.0mg USD 1650.0 2 Weeks
500.0mg USD 2650.0 2 Weeks
1.0g USD 3650.0 2 Weeks
2.0g USD 5650.0 2 Weeks
5.0g USD 8450.0 2 Weeks
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Synonym: CID-46943215; CID 46943215; CID46943215; ML266; ML 266; ML-266

IUPAC/Chemical Name: 2-(2-((4-Bromophenyl)amino)-2-oxoethoxy)-N-(2-(methyl(phenyl)amino)-2-oxoethyl)benzamide

InChi Key: VAPWBKACLHRZBZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H22BrN3O4/c1-28(19-7-3-2-4-8-19)23(30)15-26-24(31)20-9-5-6-10-21(20)32-16-22(29)27-18-13-11-17(25)12-14-18/h2-14H,15-16H2,1H3,(H,26,31)(H,27,29)

SMILES Code: CN(C1=CC=CC=C1)C(CNC(C2=CC=CC=C2OCC(NC3=CC=C(C=C3)Br)=O)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 496.361 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Rogers S, Patnaik S, Schoenen F, Zheng W, Choi J, Motabar O, Southall N, Westbroek W, Goldin E, Sidransky E, Leister W, Marugan JJ, Aubé J. Discovery, SAR, and Biological Evaluation of Non-inhibitory Chaperones of Glucocerebrosidase. 2012 Mar 27 [updated 2013 Mar 7]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. PMID: 23762943.

ML266

50.0mg / USD 550.0