WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555597

CAS#: 1065506-69-5

Description: Dafadine-A is an analog of dafadine and is a novel inhibitor of DAF-9 cytochrome P450. Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans. Dafadine-A can be used to interrogate developmental control and longevity in other animals.

Chemical Structure

CAS# 1065506-69-5

Theoretical Analysis

MedKoo Cat#: 555597
Name: Dafadine-A
CAS#: 1065506-69-5
Chemical Formula: C23H25N3O3
Exact Mass: 391.1896
Molecular Weight: 391.471
Elemental Analysis: C, 70.57; H, 6.44; N, 10.73; O, 12.26

Price and Availability

Size Price Availability Quantity
50.0mg USD 250.0 2 Weeks
100.0mg USD 450.0 2 Weeks
200.0mg USD 750.0 2 Weeks
500.0mg USD 1650.0 2 Weeks
1.0g USD 2850.0 2 Weeks
2.0g USD 5150.0 2 Weeks
5.0g USD 7950.0 2 Weeks
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Synonym: Dafadine-A

IUPAC/Chemical Name: 4-[1-({5-[(2,6-dimethylphenoxy)methyl]-3-isoxazolyl}carbonyl)-4-piperidinyl]-pyridine


InChi Code: InChI=1S/C23H25N3O3/c1-16-4-3-5-17(2)22(16)28-15-20-14-21(25-29-20)23(27)26-12-8-19(9-13-26)18-6-10-24-11-7-18/h3-7,10-11,14,19H,8-9,12-13,15H2,1-2H3


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 50.0 127.73

Preparing Stock Solutions

The following data is based on the product molecular weight 391.471 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Ma G, Wang T, Korhonen PK, Young ND, Nie S, Ang CS, Williamson NA, Reid GE, Gasser RB. Dafachronic acid promotes larval development in Haemonchus contortus by modulating dauer signalling and lipid metabolism. PLoS Pathog. 2019 Jul 23;15(7):e1007960. doi: 10.1371/journal.ppat.1007960. PMID: 31335899; PMCID: PMC6677322.

2: Luciani GM, Magomedova L, Puckrin R, Urbanus ML, Wallace IM, Giaever G, Nislow C, Cummins CL, Roy PJ. Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans. Nat Chem Biol. 2011 Nov 6;7(12):891-3. doi: 10.1038/nchembio.698. Erratum in: Nat Chem Biol. 2012 Mar;8(3):318. PMID: 22057127.