Velnacrine maleate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 576364

CAS#: 118909-22-1

Description: Velnacrine maleate is an hydroxylated derivative of the acetylcholinesterase inhibitor tacrine.

Chemical Structure

Velnacrine maleate
CAS# 118909-22-1

Theoretical Analysis

MedKoo Cat#: 576364
Name: Velnacrine maleate
CAS#: 118909-22-1
Chemical Formula: C17H18N2O5
Exact Mass: 330.1216
Molecular Weight: 330.34
Elemental Analysis: C, 61.81; H, 5.49; N, 8.48; O, 24.22

Price and Availability

Size Price Availability Quantity
250.0mg USD 255.0 2 Weeks
1.0g USD 550.0 2 Weeks
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Synonym: HP 029 maleate; HP029 maleate; HP-029 maleate; Mentane; P83 6029A; Velnacrine maleate

IUPAC/Chemical Name: 1-Acridinol, 9-amino-1,2,3,4-tetrahydro-, (+-)-, (Z)-2-butenedioate (1:1) (salt)


InChi Code: InChI=1S/C13H14N2O.C4H4O4/c14-13-8-4-1-2-5-9(8)15-10-6-3-7-11(16)12(10)13;5-3(6)1-2-4(7)8/h1-2,4-5,11,16H,3,6-7H2,(H2,14,15);1-2H,(H,5,6)(H,7,8)/b;2-1-

SMILES Code: Nc1c2C(O)CCCc2nc3ccccc13.OC(=O)\C=C/C(=O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 330.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Birks J, Wilcock GG. Velnacrine for Alzheimer's disease. Cochrane Database Syst Rev. 2004;(2):CD004748. doi: 10.1002/14651858.CD004748. PMID: 15106259.

2. Sahoo AK, Dandapat J, Dash UC, Kanhar S. Features and outcomes of drugs for combination therapy as multi-targets strategy to combat Alzheimer's disease. J Ethnopharmacol. 2018 Apr 6;215:42-73. doi: 10.1016/j.jep.2017.12.015. Epub 2017 Dec 14. PMID: 29248451.

3. Dembitsky VM, Dzhemileva L, Gloriozova T, D'yakonov V. Natural and synthetic drugs used for the treatment of the dementia. Biochem Biophys Res Commun. 2020 Apr 9;524(3):772-783. doi: 10.1016/j.bbrc.2020.01.123. Epub 2020 Feb 7. PMID: 32037088.

4. Goa KL, Fitton A. Velnacrine in Alzheimer's Disease : An Initial Appraisal of its Clinical Potential. CNS Drugs. 1994 Mar;1(3):232-40. doi: 10.2165/00023210-199401030-00008. PMID: 27520522.