Triamterene-d5 | CAS#1189922-23-3 | Triamterene quantification internal standard

Triamterene-d5
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 464345

CAS#: 1189922-23-3

Description: Triamterene-d5 is intended for use as an internal standard for the quantification of triamterene by GC- or LC-MS. Triamterene is an inhibitor of the epithelial sodium channel (ENaC; IC50 = 4.5 µM for the rat channel). In vivo, triamterene (0.5-32 mg/animal) enhances sodium secretion and decreases potassium secretion in adrenalectomized rats.2 Formulations containing triamterene have been used in the treatment of edema.

Chemical Structure

Triamterene-d5

CAS# 1189922-23-3

Instruction

Theoretical Analysis

MedKoo Cat#: 464345
Name: Triamterene-d5
CAS#: 1189922-23-3
Chemical Formula: C12H6D5N7
Exact Mass: 258.14
Molecular Weight: 258.300
Elemental Analysis: C, 55.80; H, 6.24; N, 37.96

Price and Availability

Size	Price	Availability	Quantity
1mg	USD 285	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Triamterene-d5; Triamterene d5; 2,4,7-Triamino-6-phenylpteridine-d5;

IUPAC/Chemical Name: 6-(phenyl-d5)pteridine-2,4,7-triamine

InChi Key: FNYLWPVRPXGIIP-RALIUCGRSA-N

InChi Code: InChI=1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-9/h1-5H,(H6,13,14,15,17,18,19)/i1D,2D,3D,4D,5D

SMILES Code: NC1=NC(N)=NC2=C1N=C(C(N)=N2)C3=C(C([2H])=C(C([2H])=C3[2H])[2H])[2H]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 258.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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3: Hu LX, Wang D, Liu HL, Zhang QT, Sun DS, Zhang L, Chen X, Chang GL, Wang JG. A double-blind, placebo-controlled trial on the antihypertensive treatment effect of a quadruple single-pill combination. J Clin Hypertens (Greenwich). 2021 Feb 6. doi: 10.1111/jch.14207. Epub ahead of print. PMID: 33548084.

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