WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 464335
CAS#: unknown
Description: Nanangenine C is a drimane sesquiterpene that has been found in Aspergillus. It is active against B. subtilis (IC50 = 5.7 µg/ml) and cytotoxic to NS-1 mouse myeloma cells (IC50 = 4.1 µg/ml).
MedKoo Cat#: 464335
Name: Nanangenine C
CAS#: unknown
Chemical Formula: C21H32O5
Exact Mass: 364.225
Molecular Weight: 364.482
Elemental Analysis: C, 69.20; H, 8.85; O, 21.95
Synonym: Nanangenine C; Nanangenine-C;
IUPAC/Chemical Name: (5R,5aS,9aS,9bS)-9b-hydroxy-6,6,9a-trimethyl-1-oxo-1,3,5,5a,6,7,8,9,9a,9b-decahydronaphtho[1,2-c]furan-5-yl hexanoate
InChi Key: ROECGAWNHRGIRN-GWKIZSTFSA-N
InChi Code: InChI=1S/C21H32O5/c1-5-6-7-9-16(22)26-15-12-14-13-25-18(23)21(14,24)20(4)11-8-10-19(2,3)17(15)20/h12,15,17,24H,5-11,13H2,1-4H3/t15-,17+,20+,21+/m1/s1
SMILES Code: CC1(CCC[C@]2([C@]1([C@@H](C=C([C@@]23O)COC3=O)OC(CCCCC)=O)[H])C)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
| Biological target: | Nanangenine C is a drimane sesquiterpene that is active against B. subtilis (IC50 = 5.7 µg/ml) and cytotoxic to NS-1 mouse myeloma cells (IC50 = 4.1 µg/ml). |
| In vitro activity: | TBD |
| In vivo activity: | TBD |
The following data is based on the product molecular weight 364.482 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | TBD |
| In vitro protocol: | TBD |
| In vivo protocol: | TBD |
1: Lacey HJ, Gilchrist CLM, Crombie A, Kalaitzis JA, Vuong D, Rutledge PJ, Turner P, Pitt JI, Lacey E, Chooi YH, Piggott AM. Nanangenines: drimane sesquiterpenoids as the dominant metabolite cohort of a novel Australian fungus, Aspergillus nanangensis. Beilstein J Org Chem. 2019 Nov 5;15:2631-2643. doi: 10.3762/bjoc.15.256. PMID: 31807198; PMCID: PMC6880815.
