WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 464329
CAS#: 34023-62-6
Description: 1-BCP is a positive allosteric modulator of AMPA receptors. 1-BCP (1 mM) selectively increases the release of norepinephrine induced by AMPA, but not NMDA or kainic acid, in rat hippocampal slices. It increases the amplitude and duration of primed field excitatory postsynaptic potentials (EPSPs) in rat hippocampal slices (EC50s = 480 and 590 µM, respectively). 1-BCP enhances memory in two-odor discrimination and radial maze tests, as well as in the Morris water maze, in rats when administered at a dose of 120 mg/kg.
MedKoo Cat#: 464329
Name: 1-BCP
CAS#: 34023-62-6
Chemical Formula: C13H15NO3
Exact Mass: 233.1052
Molecular Weight: 233.267
Elemental Analysis: C, 66.94; H, 6.48; N, 6.00; O, 20.58
Synonym: 1-BCP; 1BCP; 1 BCP;
IUPAC/Chemical Name: benzo[d][1,3]dioxol-5-yl(piperidin-1-yl)methanone
InChi Key: BXBNADAPIHHXJQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C13H15NO3/c15-13(14-6-2-1-3-7-14)10-4-5-11-12(8-10)17-9-16-11/h4-5,8H,1-3,6-7,9H2
SMILES Code: O=C(C1=CC=C2OCOC2=C1)N3CCCCC3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMF | 20.0 | ||
| DMSO | 10.0 | ||
| Ethanol | 30.0 |
The following data is based on the product molecular weight 233.267 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Fan WT, Wu XL, Pan YL, Niu YB, Li CR, Mei QB. [Synthesis and antifatigue activities of new benzamide derivatives]. Yao Xue Xue Bao. 2014 Oct;49(10):1442-5. Chinese. PMID: 25577876.
2: Wu X, Fan W, Pan Y, Zhai Y, Niu Y, Li C, Mei Q. Synthesis, crystal structure and anti-fatigue effects of some benzamide derivatives. Molecules. 2014 Jan 16;19(1):1034-46. doi: 10.3390/molecules19011034. PMID: 24441653; PMCID: PMC6271547.
3: Fan W, Wu X, Pan Y, Li C, Niu Y, Zhai Y, Mei Q. 1-(1,3-Benzodioxol-5-yl- carbo-nyl) piperidine, a modulator of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor, ameliorates exercise-induced fatigue in mice. Biol Pharm Bull. 2014;37(1):13-7. doi: 10.1248/bpb.b13-00399. Epub 2013 Oct 19. PMID: 24141261.
