1-BCP
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 464329

CAS#: 34023-62-6

Description: 1-BCP is a positive allosteric modulator of AMPA receptors. 1-BCP (1 mM) selectively increases the release of norepinephrine induced by AMPA, but not NMDA or kainic acid, in rat hippocampal slices. It increases the amplitude and duration of primed field excitatory postsynaptic potentials (EPSPs) in rat hippocampal slices (EC50s = 480 and 590 µM, respectively). 1-BCP enhances memory in two-odor discrimination and radial maze tests, as well as in the Morris water maze, in rats when administered at a dose of 120 mg/kg.

Chemical Structure

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1-BCP
CAS# 34023-62-6
Instruction

Theoretical Analysis

MedKoo Cat#: 464329
Name: 1-BCP
CAS#: 34023-62-6
Chemical Formula: C13H15NO3
Exact Mass: 233.11
Molecular Weight: 233.267
Elemental Analysis: C, 66.94; H, 6.48; N, 6.00; O, 20.58

Price and Availability

Size Price Availability Quantity
5mg USD 250 2 Weeks
10mg USD 450 2 Weeks
25mg USD 750 2 Weeks
50mg USD 1350 2 Weeks
Bulk inquiry

Synonym: 1-BCP; 1BCP; 1 BCP;

IUPAC/Chemical Name: benzo[d][1,3]dioxol-5-yl(piperidin-1-yl)methanone

InChi Key: BXBNADAPIHHXJQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H15NO3/c15-13(14-6-2-1-3-7-14)10-4-5-11-12(8-10)17-9-16-11/h4-5,8H,1-3,6-7,9H2

SMILES Code: O=C(C1=CC=C2OCOC2=C1)N3CCCCC3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMF 20.0 0.00
DMSO 10.0 0.00
Ethanol 30.0 0.00

Preparing Stock Solutions

The following data is based on the product molecular weight 233.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Fan WT, Wu XL, Pan YL, Niu YB, Li CR, Mei QB. [Synthesis and antifatigue activities of new benzamide derivatives]. Yao Xue Xue Bao. 2014 Oct;49(10):1442-5. Chinese. PMID: 25577876.

2: Wu X, Fan W, Pan Y, Zhai Y, Niu Y, Li C, Mei Q. Synthesis, crystal structure and anti-fatigue effects of some benzamide derivatives. Molecules. 2014 Jan 16;19(1):1034-46. doi: 10.3390/molecules19011034. PMID: 24441653; PMCID: PMC6271547.

3: Fan W, Wu X, Pan Y, Li C, Niu Y, Zhai Y, Mei Q. 1-(1,3-Benzodioxol-5-yl- carbo-nyl) piperidine, a modulator of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor, ameliorates exercise-induced fatigue in mice. Biol Pharm Bull. 2014;37(1):13-7. doi: 10.1248/bpb.b13-00399. Epub 2013 Oct 19. PMID: 24141261.