WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 555941
CAS#: 955371-66-1
Description: VK-II-36 is a Carvedilol analogue inhibits triggered activities evoked by both early and delayed after depolarizations. VK-II-36 inhibits ventricular tachyarrhythmias in intact mouse and rabbit ventricles by the suppression of SCaEs, independent of beta-blocking activity. The RyR2 may be a potential target for treating focal ventricular arrhythmias triggered by either EADs or DADs.
MedKoo Cat#: 555941
Name: VK-II-36
CAS#: 955371-66-1
Chemical Formula: C26H26N2O5
Exact Mass: 446.1842
Molecular Weight: 446.503
Elemental Analysis: C, 69.94; H, 5.87; N, 6.27; O, 17.92
Synonym: VK-II-36; VK-II 36; VK-II36; VK II36; VKII36;
IUPAC/Chemical Name: 6-[(9H-Carbazol-4-yloxy)methyl]-4-[2-(2-methoxyphenoxy)ethyl]-3-morpholinone
InChi Key: OPUVSUMPCOUABG-UHFFFAOYSA-N
InChi Code: InChI=1S/C26H26N2O5/c1-30-22-10-4-5-11-23(22)31-14-13-28-15-18(32-17-25(28)29)16-33-24-12-6-9-21-26(24)19-7-2-3-8-20(19)27-21/h2-12,18,27H,13-17H2,1H3
SMILES Code: COC1=CC=CC=C1OCCN2CC(COC3=CC=CC(N4)=C3C5=C4C=CC=C5)OCC2=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 446.503 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Shinohara T, Kim D, Joung B, Maruyama M, Vembaiyan K, Back TG, Wayne Chen SR, Chen PS, Lin SF. Carvedilol analog modulates both basal and stimulated sinoatrial node automaticity. Heart Vessels. 2014 May;29(3):396-403. doi: 10.1007/s00380-013-0378-2. Epub 2013 Jul 9. PMID: 23836067; PMCID: PMC3849120.
2: Maruyama M, Xiao J, Zhou Q, Vembaiyan K, Chua SK, Rubart-von der Lohe M, Lin SF, Back TG, Chen SR, Chen PS. Carvedilol analogue inhibits triggered activities evoked by both early and delayed afterdepolarizations. Heart Rhythm. 2013 Jan;10(1):101-7. doi: 10.1016/j.hrthm.2012.09.006. Epub 2012 Sep 14. PMID: 22982970; PMCID: PMC3534812.
