WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555941

CAS#: 955371-66-1

Description: VK-II-36 is a Carvedilol analogue inhibits triggered activities evoked by both early and delayed after depolarizations. VK-II-36 inhibits ventricular tachyarrhythmias in intact mouse and rabbit ventricles by the suppression of SCaEs, independent of beta-blocking activity. The RyR2 may be a potential target for treating focal ventricular arrhythmias triggered by either EADs or DADs.

Chemical Structure

CAS# 955371-66-1

Theoretical Analysis

MedKoo Cat#: 555941
Name: VK-II-36
CAS#: 955371-66-1
Chemical Formula: C26H26N2O5
Exact Mass: 446.1842
Molecular Weight: 446.503
Elemental Analysis: C, 69.94; H, 5.87; N, 6.27; O, 17.92

Price and Availability

Size Price Availability Quantity
25.0mg USD 350.0 2 Weeks
50.0mg USD 550.0 2 Weeks
100.0mg USD 950.0 2 Weeks
200.0mg USD 1450.0 2 Weeks
500.0mg USD 2450.0 2 Weeks
1.0g USD 3450.0 2 Weeks
2.0g USD 5450.0 2 Weeks
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Synonym: VK-II-36; VK-II 36; VK-II36; VK II36; VKII36;

IUPAC/Chemical Name: 6-[(9H-Carbazol-4-yloxy)methyl]-4-[2-(2-methoxyphenoxy)ethyl]-3-morpholinone


InChi Code: InChI=1S/C26H26N2O5/c1-30-22-10-4-5-11-23(22)31-14-13-28-15-18(32-17-25(28)29)16-33-24-12-6-9-21-26(24)19-7-2-3-8-20(19)27-21/h2-12,18,27H,13-17H2,1H3


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 446.503 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Shinohara T, Kim D, Joung B, Maruyama M, Vembaiyan K, Back TG, Wayne Chen SR, Chen PS, Lin SF. Carvedilol analog modulates both basal and stimulated sinoatrial node automaticity. Heart Vessels. 2014 May;29(3):396-403. doi: 10.1007/s00380-013-0378-2. Epub 2013 Jul 9. PMID: 23836067; PMCID: PMC3849120.

2: Maruyama M, Xiao J, Zhou Q, Vembaiyan K, Chua SK, Rubart-von der Lohe M, Lin SF, Back TG, Chen SR, Chen PS. Carvedilol analogue inhibits triggered activities evoked by both early and delayed afterdepolarizations. Heart Rhythm. 2013 Jan;10(1):101-7. doi: 10.1016/j.hrthm.2012.09.006. Epub 2012 Sep 14. PMID: 22982970; PMCID: PMC3534812.


25.0mg / USD 350.0