WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 555936
CAS#: 1599440-15-9
Description: MC-Gly-Gly-Phe is a cleavable linker used for antibody-drug conjugates (ADC).
MedKoo Cat#: 555936
Name: MC-Gly-Gly-Phe
CAS#: 1599440-15-9
Chemical Formula: C23H28N4O7
Exact Mass: 472.1958
Molecular Weight: 472.498
Elemental Analysis: C, 58.47; H, 5.97; N, 11.86; O, 23.70
Synonym: MC-Gly-Gly-Phe;
IUPAC/Chemical Name: (6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl)glycylglycyl-L-phenylalanine
InChi Key: NFVPAFLSJIPUCL-KRWDZBQOSA-N
InChi Code: InChI=1S/C23H28N4O7/c28-18(9-5-2-6-12-27-21(31)10-11-22(27)32)24-14-19(29)25-15-20(30)26-17(23(33)34)13-16-7-3-1-4-8-16/h1,3-4,7-8,10-11,17H,2,5-6,9,12-15H2,(H,24,28)(H,25,29)(H,26,30)(H,33,34)/t17-/m0/s1
SMILES Code: O=C(O)[C@H](CC1=CC=CC=C1)NC(CNC(CNC(CCCCCN2C(C=CC2=O)=O)=O)=O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
| Biological target: | MC-Gly-Gly-Phe is a cleavable linker used for antibody-drug conjugates (ADC). |
| In vitro activity: | TBD |
| In vivo activity: | TBD |
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 50.0 | 105.82 |
The following data is based on the product molecular weight 472.498 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | TBD |
| In vitro protocol: | TBD |
| In vivo protocol: | TBD |
