Hesperetin dihydrochalcone

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 576257

CAS#: 35400-60-3

Description: Hesperetin dihydrochalcone is an antioxidant flavonoid. It induces G1-phase cell cycle arrest. It is also anti-inflammatory. Hesperetin suppresses NF-κB activation and reduces cholesterol biosynthesis. Hespertin is also neuroprotective against neuronal oxidative damage.


Chemical Structure

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Hesperetin dihydrochalcone
CAS# 35400-60-3

Theoretical Analysis

MedKoo Cat#: 576257
Name: Hesperetin dihydrochalcone
CAS#: 35400-60-3
Chemical Formula: C16H16O6
Exact Mass: 304.09
Molecular Weight: 304.300
Elemental Analysis: C, 63.15; H, 5.30; O, 31.55

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Hesperetin dihydrochalcone

IUPAC/Chemical Name: 1-Propanone, 3-(3-hydroxy-4-methoxyphenyl)-1-(2,4,6-trihydroxyphenyl)-

InChi Key: RWKSTZADJBEXSQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H16O6/c1-22-15-5-3-9(6-12(15)19)2-4-11(18)16-13(20)7-10(17)8-14(16)21/h3,5-8,17,19-21H,2,4H2,1H3

SMILES Code: COc1ccc(CCC(=O)c2c(O)cc(O)cc2O)cc1O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 304.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Yang LJ, Xia S, Ma SX, Zhou SY, Zhao XQ, Wang SH, Li MY, Yang XD. Host-guest system of hesperetin and β-cyclodextrin or its derivatives: Preparation, characterization, inclusion mode, solubilization and stability. Mater Sci Eng C Mater Biol Appl. 2016 Feb 1;59:1016-24. doi: 10.1016/j.msec.2015.10.037. Epub 2015 Oct 23. PubMed PMID: 26652460.

2: de Souza VT, de Franco ÉP, de Araújo ME, Messias MC, Priviero FB, Frankland Sawaya AC, de Oliveira Carvalho P. Characterization of the antioxidant activity of aglycone and glycosylated derivatives of hesperetin: an in vitro and in vivo study. J Mol Recognit. 2016 Feb;29(2):80-7. doi: 10.1002/jmr.2509. Epub 2015 Sep 15. PubMed PMID: 26370929.

3: Wei L, Deng W, Cheng Z, Guo H, Wang S, Zhang X, He Y, Tang Q. Effects of hesperetin on platelet-derived growth factor-BB-induced pulmonary artery smooth muscle cell proliferation. Mol Med Rep. 2016 Jan;13(1):955-60. doi: 10.3892/mmr.2015.4625. Epub 2015 Nov 30. PubMed PMID: 26647836.

4: Shen C, Chen R, Qian Z, Huang C, Meng X, Ma T, Chen Z, Huang X, Li L, Zang H, Li J. A HPLC-MS/MS method for the quantitation of free, conjugated, and total HDND-7, a novel hesperetin derivative, in rat plasma and tissues: Application to the pharmacokinetic and tissue distribution study. J Pharm Biomed Anal. 2016 Jan 25;118:149-60. doi: 10.1016/j.jpba.2015.10.031. Epub 2015 Oct 27. PubMed PMID: 26551533.

5: Wang QQ, Shi JB, Chen C, Huang C, Tang WJ, Li J. Hesperetin derivatives: Synthesis and anti-inflammatory activity. Bioorg Med Chem Lett. 2016 Mar 1;26(5):1460-5. doi: 10.1016/j.bmcl.2016.01.058. Epub 2016 Jan 22. PubMed PMID: 26848111.