Hematoporphyrin dipentyl ether

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MedKoo CAT#: 576237

CAS#: 109351-24-8

Description: Hematoporphyrin dipentyl ether is an iron-free derivative of heme with 4 methyl groups, 2 hydroxyethyl groups, and 2 propionic acid groups attached to the pyrrole rings. Some of these photosensitizing agents are used in the phototherapy of malignant neoplasms.

Chemical Structure

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Hematoporphyrin dipentyl ether
CAS# 109351-24-8
Instruction

Theoretical Analysis

MedKoo Cat#: 576237
Name: Hematoporphyrin dipentyl ether
CAS#: 109351-24-8
Chemical Formula: C44H58N4O6
Exact Mass: 738.44
Molecular Weight: 738.970
Elemental Analysis: C, 71.52; H, 7.91; N, 7.58; O, 12.99

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
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Synonym: Hematoporphyrin dipentyl ether; HP-Diamyl ether

IUPAC/Chemical Name: 21H,23H-Porphine-2,18-dipropanoic acid, 3,7,12,17-tetramethyl-8,13-bis(1-(pentyloxy)ethyl)-

InChi Key: FXBWDHMUVXTBKG-OKYITIEZSA-N

InChi Code: InChI=1S/C44H58N4O6/c1-9-11-13-19-53-29(7)43-27(5)35-21-33-25(3)31(15-17-41(49)50)37(45-33)24-38-32(16-18-42(51)52)26(4)34(46-38)22-39-44(30(8)54-20-14-12-10-2)28(6)36(48-39)23-40(43)47-35/h21-24,29-30,45,48H,9-20H2,1-8H3,(H,49,50)(H,51,52)/b33-21-,34-22-,35-21-,36-23-,37-24-,38-24-,39-22-,40-23-

SMILES Code: CCCCCOC(C)C1=C(C)c2cc3nc(cc4[nH]c(cc5nc(cc1[nH]2)c(C)c5CCC(=O)O)c(CCC(=O)O)c4C)c(C)c3C(C)OCCCCC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 738.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Kessel D. Hematoporphyrin and HPD: photophysics, photochemistry and phototherapy. Photochem Photobiol. 1984 Jun;39(6):851-9. doi: 10.1111/j.1751-1097.1984.tb08871.x. PMID: 6235529.

2. Lei TC, Glazner GF, Duffy M, Scherrer L, Pendyala S, Li B, Wang X, Wang H, Huang Z. Optical properties of hematoporphyrin monomethyl ether (HMME), a PDT photosensitizer. Photodiagnosis Photodyn Ther. 2012 Sep;9(3):232-42. doi: 10.1016/j.pdpdt.2012.01.003. Epub 2012 Feb 10. PMID: 22959803.