WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555929

CAS#: 218457-67-1

Description: CB-103 is a γ-secretase inhibitor. CB-103 inhibits Notch signaling in primary human T cell acute lymphoblastic leukemia and other Notch-dependent human tumor cell lines, and concomitantly induces cell cycle arrest and apoptosis, thereby impairing proliferation, including in GSI-resistant human tumor cell lines with chromosomal translocations and rearrangements in Notch genes. CB-103 produces Notch loss-of-function phenotypes in flies and mice and inhibits the growth of human breast cancer and leukemia xenografts, notably without causing the dose-limiting intestinal toxicity associated with other Notch inhibitors.

Chemical Structure

CAS# 218457-67-1

Theoretical Analysis

MedKoo Cat#: 555929
Name: CB-103
CAS#: 218457-67-1
Chemical Formula: C15H18N2O
Exact Mass: 242.1419
Molecular Weight: 242.322
Elemental Analysis: C, 74.35; H, 7.49; N, 11.56; O, 6.60

Price and Availability

Size Price Availability Quantity
100.0mg USD 150.0 2 Weeks
200.0mg USD 250.0 2 Weeks
500.0mg USD 550.0 2 Weeks
1.0g USD 950.0 2 Weeks
2.0g USD 1650.0 2 Weeks
5.0g USD 3500.0 2 Weeks
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Synonym: CB-103; CB 103; CB103;

IUPAC/Chemical Name: 5-Amino-2-(4-tert-butylphenoxy)pyridine


InChi Code: InChI=1S/C15H18N2O/c1-15(2,3)11-4-7-13(8-5-11)18-14-9-6-12(16)10-17-14/h4-10H,16H2,1-3H3


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 50.0 206.63

Preparing Stock Solutions

The following data is based on the product molecular weight 242.322 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Fabbro D, Bauer M, Murone M, Lehal R. Notch Inhibition in Cancer: Challenges and Opportunities. Chimia (Aarau). 2020 Oct 28;74(10):779-783. doi: 10.2533/chimia.2020.779. PMID: 33115560.

2: Lehal R, Zaric J, Vigolo M, Urech C, Frismantas V, Zangger N, Cao L, Berger A, Chicote I, Loubéry S, Choi SH, Koch U, Blacklow SC, Palmer HG, Bornhauser B, González-Gaitán M, Arsenijevic Y, Zoete V, Aster JC, Bourquin JP, Radtke F. Pharmacological disruption of the Notch transcription factor complex. Proc Natl Acad Sci U S A. 2020 Jul 14;117(28):16292-16301. doi: 10.1073/pnas.1922606117. Epub 2020 Jun 29. PMID: 32601208; PMCID: PMC7368267.


100.0mg / USD 150.0