WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555927

CAS#: 161401-82-7

Description: Z-VAD(OH)-FMK, also known as Z-Val-Ala-Asp-(OH)-Fluoromethyl Ketone, is an irreversible tripeptide inhibitor of all caspases.

Chemical Structure

CAS# 161401-82-7

Theoretical Analysis

MedKoo Cat#: 555927
CAS#: 161401-82-7
Chemical Formula: C21H28FN3O7
Exact Mass: 453.19
Molecular Weight: 453.467
Elemental Analysis: C, 55.62; H, 6.22; F, 4.19; N, 9.27; O, 24.70

Price and Availability

Size Price Availability Quantity
25mg USD 2450 2 Weeks
50mg USD 4250 2 Weeks
100mg USD 7650 2 Weeks
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Synonym: Z-VAD(OH)-FMK; Z-Val-Ala-Asp-(OH)-Fluoromethyl Ketone;

IUPAC/Chemical Name: (5S,8S,11S)-11-(2-fluoroacetyl)-5-isopropyl-8-methyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazatridecan-13-oic acid


InChi Code: InChI=1S/C21H28FN3O7/c1-12(2)18(25-21(31)32-11-14-7-5-4-6-8-14)20(30)23-13(3)19(29)24-15(9-17(27)28)16(26)10-22/h4-8,12-13,15,18H,9-11H2,1-3H3,(H,23,30)(H,24,29)(H,25,31)(H,27,28)/t13-,15-,18-/m0/s1

SMILES Code: O=C(O)C[C@@H](C(CF)=O)NC([C@H](C)NC([C@H](C(C)C)NC(OCC1=CC=CC=C1)=O)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 5.0 11.00

Preparing Stock Solutions

The following data is based on the product molecular weight 453.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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18: Kim HB, Kim MJ, Lee SH, Lee JW, Bae JH, Kim DW, Dao TT, Oh WK, Kang CD, Kim SH. Amurensin G, a novel SIRT1 inhibitor, sensitizes TRAIL-resistant human leukemic K562 cells to TRAIL-induced apoptosis. Biochem Pharmacol. 2012 Aug 1;84(3):402-10. doi: 10.1016/j.bcp.2012.03.014. Epub 2012 Mar 29. PMID: 22483777.

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20: Fossey SL, Bear MD, Lin J, Li C, Schwartz EB, Li PK, Fuchs JR, Fenger J, Kisseberth WC, London CA. The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines. BMC Cancer. 2011 Mar 28;11:112. doi: 10.1186/1471-2407-11-112. PMID: 21443800; PMCID: PMC3074561.