Halofantrine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 576178

CAS#: 69756-53-2

Description: Halofantrine is a blocker of delayed rectifier potassium current via the inhibition of hERG channel.


Chemical Structure

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Halofantrine
CAS# 69756-53-2

Theoretical Analysis

MedKoo Cat#: 576178
Name: Halofantrine
CAS#: 69756-53-2
Chemical Formula: C26H36F3NO
Exact Mass: 435.2749
Molecular Weight: 435.58
Elemental Analysis: C, 71.70; H, 8.33; F, 13.09; N, 3.22; O, 3.67

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: dl-WR 171669; Halfan; Halofantrine

IUPAC/Chemical Name: 9-Phenanthrenemethanol, 1,3-dihydro-alpha-(2-(dibutylamino)ethyl)-6-(trifluoromethyl)-

InChi Key: FOHHNHSLJDZUGQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H30Cl2F3NO/c1-3-5-10-32(11-6-4-2)12-9-25(33)23-16-22-21(14-18(27)15-24(22)28)20-13-17(26(29,30)31)7-8-19(20)23/h7-8,13-16,25,33H,3-6,9-12H2,1-2H3

SMILES Code: CCCCN(CCCC)CCC(O)c1cc2c(Cl)cc(Cl)cc2c3cc(ccc13)C(F)(F)F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: to be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 435.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Reconstitution Calculator

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Dilution Calculator

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1: Khoo SM, Prankerd RJ, Edwards GA, Porter CJ, Charman WN. A physicochemical basis for the extensive intestinal lymphatic transport of a poorly lipid soluble antimalarial, halofantrine hydrochloride, after postprandial administration to dogs. J Pharm Sci. 2002 Mar;91(3):647-59. PubMed PMID: 11920750.

2: Del Nero L, Lamizana L, Nebie I, Sare S, Bougouma L, Pietra V. In vivo sensitivity of Plasmodium falciparum to halofantrine hydrochloride in Burkina Faso. Am J Trop Med Hyg. 1994 Jan;50(1):102-6. PubMed PMID: 8304564.

3: Gillespie SH, Msaki EP, Ramsay A, Ngowi FI, Fox R. A new micronized formulation of halofantrine hydrochloride in the treatment of acute Plasmodium falciparum malaria. Trans R Soc Trop Med Hyg. 1993 Jul-Aug;87(4):467-9. PubMed PMID: 8249083.

4: Khan MA, Rehman GN, Qazi SA. Halofantrine hydrochloride--efficacy and safety in children with acute malaria. J Pak Med Assoc. 1991 Jan;41(1):8-10. PubMed PMID: 1900550.