WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 576174
CAS#: 201943-88-6
Description: HA-7 is an anti-arrhythmic agent.
MedKoo Cat#: 576174
Name: HA-7
CAS#: 201943-88-6
Chemical Formula: C19H15NO4
Exact Mass: 321.1001
Molecular Weight: 321.33
Elemental Analysis: C, 71.02; H, 4.71; N, 4.36; O, 19.92
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Synonym: HA-7; HA 7; HA7
IUPAC/Chemical Name: FURO(2,3-b)quinoline-3,4(2H,9H)-dione, 7-methoxy-9-(phenylmethyl)-
InChi Key: GUAIXKMHFDVZEQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H15NO4/c1-23-13-7-8-14-15(9-13)20(10-12-5-3-2-4-6-12)19-17(18(14)22)16(21)11-24-19/h2-9H,10-11H2,1H3
SMILES Code: COc1ccc2C(=O)C3=C(OCC3=O)N(Cc4ccccc4)c2c1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: to be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 321.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1. Chang GJ, Su MJ, Kuo SC, Lin TP, Lee YS. Multiple cellular electrophysiological effects of a novel antiarrhythmic furoquinoline derivative HA-7 [N-benzyl-7-methoxy-2,3,4,9-tetrahydrofuro[2,3-b]quinoline-3,4-dione] in guinea pig cardiac preparations. J Pharmacol Exp Ther. 2006 Jan;316(1):380-91. doi: 10.1124/jpet.105.092106. Epub 2005 Sep 20. PMID: 16174797.
2. Su MJ, Chang GJ, Wu MH, Kuo SC. Electrophysiological basis for the antiarrhythmic action and positive inotropy of HA-7, a furoquinoline alkaloid derivative, in rat heart. Br J Pharmacol. 1997 Dec;122(7):1285-98. doi: 10.1038/sj.bjp.0701510. PMID: 9421274; PMCID: PMC1565072.
