Dasiglucagon

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 413480

CAS#: 1544300-84-6

Description: Dasiglucagon is used in the treatment of Hypoglycemia in Type 1 and Type 2 Diabetes Patients. asiglucagon is an analog of human glucagon that is stable in aqueous formulation, for the treatment of type 1 diabetes in a dual-hormone artificial pancreas pump containing both insulin and glucagon. Dasiglucagon, a stable peptide analog of human glucagon, is a fast and effective treatment option for severe hypoglycemia. Dasiglucagon was approved in March 2021.


Chemical Structure

img
Dasiglucagon
CAS# 1544300-84-6

Theoretical Analysis

MedKoo Cat#: 413480
Name: Dasiglucagon
CAS#: 1544300-84-6
Chemical Formula: C152H222N38O50
Exact Mass: 3,379.60
Molecular Weight: 3,381.660
Elemental Analysis: C, 53.99; H, 6.62; N, 15.74; O, 23.66

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Dasiglucagon; ZP4207; ZP 4207; ZP-4207

IUPAC/Chemical Name: L-Threonine, L-histidyl-L-seryl-L-glutaminylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-alpha-aspartyl-2-methylalanyl-L-alanyl-L-arginyl-L-alanyl-L-alpha-glutamyl-L-alpha

InChi Key: RZRMFQMNPDPAIX-AJTOSFMRSA-N

InChi Code: InChI=1S/C152H222N38O50/c1-73(2)55-99(133(222)171-98(47-51-116(206)207)132(221)183-111(71-194)144(233)189-122(80(11)197)149(238)239)174-137(226)105(61-85-65-161-91-32-21-20-31-89(85)91)178-129(218)93(34-23-25-53-154)172-146(235)119(75(5)6)187-139(228)103(57-81-27-16-14-17-28-81)176-131(220)97(46-50-115(204)205)170-130(219)96(45-49-114(202)203)167-123(212)76(7)164-127(216)94(35-26-54-160-151(157)158)166-124(213)77(8)165-150(240)152(12,13)190-145(234)107(64-118(210)211)180-134(223)100(56-74(3)4)173-135(224)101(59-83-36-40-87(198)41-37-83)175-128(217)92(33-22-24-52-153)168-142(231)109(69-192)184-136(225)102(60-84-38-42-88(199)43-39-84)177-138(227)106(63-117(208)209)179-143(232)110(70-193)185-148(237)121(79(10)196)188-140(229)104(58-82-29-18-15-19-30-82)181-147(236)120(78(9)195)186-113(201)67-162-126(215)95(44-48-112(156)200)169-141(230)108(68-191)182-125(214)90(155)62-86-66-159-72-163-86/h14-21,27-32,36-43,65-66,72-80,90,92-111,119-122,161,191-199H,22-26,33-35,44-64,67-71,153-155H2,1-13H3,(H2,156,200)(H,159,163)(H,162,215)(H,164,216)(H,165,240)(H,166,213)(H,167,212)(H,168,231)(H,169,230)(H,170,219)(H,171,222)(H,172,235)(H,173,224)(H,174,226)(H,175,217)(H,176,220)(H,177,227)(H,178,218)(H,179,232)(H,180,223)(H,181,236)(H,182,214)(H,183,221)(H,184,225)(H,185,237)(H,186,201)(H,187,228)(H,188,229)(H,189,233)(H,190,234)(H,202,203)(H,204,205)(H,206,207)(H,208,209)(H,210,211)(H,238,239)(H4,157,158,160)/t76-,77-,78+,79+,80+,90-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,119-,120-,121-,122-/m0/s1

SMILES Code: CC(C[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)[C@H](O)C)=O)CO)=O)CCC(O)=O)=O)NC([C@@H](NC([C@@H](NC([C@H](C(C)C)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(C(C)(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H]([C@H](O)C)NC([C@@H](NC([C@H]([C@H](O)C)NC(CNC([C@@H](NC([C@@H](NC([C@H](Cc1nc[nH]c1)N)=O)CO)=O)CCC(N)=O)=O)=O)=O)Cc2ccccc2)=O)=O)CO)=O)CC(O)=O)=O)Cc3ccc(O)cc3)=O)CO)=O)CCCCN)=O)Cc4ccc(O)cc4)=O)CC(C)C)=O)CC(O)=O)=O)C)=O)C)=O)CCCNC(N)=N)=O)C)=O)CCC(O)=O)=O)CCC(O)=O)=O)Cc5ccccc5)=O)=O)CCCCN)=O)Cc(c[nH]6)c7c6cccc7)=O)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: to be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
To be determined 0.0 100.00

Preparing Stock Solutions

The following data is based on the product molecular weight 3,381.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Li S, Hu Y, Tan X, Wang D, Hu J, Zou P, Wang L. Evaluating dasiglucagon as a treatment option for hypoglycemia in diabetes. Expert Opin Pharmacother. 2020 Aug;21(11):1311-1318. doi: 10.1080/14656566.2020.1747432. Epub 2020 Apr 8. PMID: 32267182.

2: Hawkes CP, De Leon DD, Rickels MR. Novel Preparations of Glucagon for the Prevention and Treatment of Hypoglycemia. Curr Diab Rep. 2019 Sep 6;19(10):97. doi: 10.1007/s11892-019-1216-4. PMID: 31493043; PMCID: PMC6951434.

3: Castle JR, Elander M. Long-Term Safety and Tolerability of Dasiglucagon, a Stable-in-Solution Glucagon Analogue. Diabetes Technol Ther. 2019 Feb;21(2):94-96. doi: 10.1089/dia.2018.0363. PMID: 30707621.

4: Hövelmann U, Olsen MB, Mouritzen U, Lamers D, Kronshage B, Heise T. Low doses of dasiglucagon consistently increase plasma glucose levels from hypoglycaemia and euglycaemia in people with type 1 diabetes mellitus. Diabetes Obes Metab. 2019 Mar;21(3):601-610. doi: 10.1111/dom.13562. Epub 2018 Nov 28. PMID: 30350477; PMCID: PMC6587565.

5: Hövelmann U, Bysted BV, Mouritzen U, Macchi F, Lamers D, Kronshage B, Møller DV, Heise T. Pharmacokinetic and Pharmacodynamic Characteristics of Dasiglucagon, a Novel Soluble and Stable Glucagon Analog. Diabetes Care. 2018 Mar;41(3):531-537. doi: 10.2337/dc17-1402. Epub 2017 Dec 22. PMID: 29273578.

6: Lam S. American Diabetes Association - 77th Scientific Sessions (June 9-13, 2017 - San Diego, California, USA). Drugs Today (Barc). 2017 Jul;53(7):405-413. doi: 10.1358/dot.2017.53.7.2669148. PMID: 28837185.