WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 576151
Description: H 218-54 is a renin inhibitor.
MedKoo Cat#: 576151
Name: H 218-54
Chemical Formula: C37H56N2O5S
Exact Mass: 640.391
Molecular Weight: 640.92
Elemental Analysis: C, 69.34; H, 8.81; N, 4.37; O, 12.48; S, 5.00
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: H 218-54; H218-54; H-218-54
IUPAC/Chemical Name: Benzenepropanamide, N-(1-(((1-(cyclohexylmethyl)-2-hydroxy-4-methyl-5-((1-methylethyl)sulfonyl)pentyl)amino)carbonyl)butyl)-alpha-(phenylmethyl)-, (1S-(1R*(R*),2R*,4S*))-
InChi Key: NVRDSEWNJXFSGD-UMZFBTNNSA-N
InChi Code: InChI=1S/C37H56N2O5S/c1-5-15-33(38-36(41)32(23-29-16-9-6-10-17-29)24-30-18-11-7-12-19-30)37(42)39-34(25-31-20-13-8-14-21-31)35(40)22-28(4)26-45(43,44)27(2)3/h6-7,9-12,16-19,27-28,31-35,40H,5,8,13-15,20-26H2,1-4H3,(H,38,41)(H,39,42)/t28-,33?,34+,35+/m1/s1
SMILES Code: CCCC(NC(=O)C(Cc1ccccc1)Cc2ccccc2)C(=O)N[C@@H](CC3CCCCC3)[C@@H](O)C[C@@H](C)CS(=O)(=O)C(C)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: to be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 640.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1. Renberg L, Hoffmann KJ. Determination of a renin inhibitor in plasma by solid-phase extraction using acetone as protein binding displacer followed by on-line high-performance liquid chromatography. J Pharm Biomed Anal. 1992 Oct-Dec;10(10-12):959-63. doi: 10.1016/0731-7085(91)80105-i. PMID: 1298403.