WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 413470
CAS#: 133099-04-4 (free base)
Description: Darifenacin Free Base is a Muscarinic M(3) receptor antagonist that is indicated for use in treatment of overactive bladder disorder.
MedKoo Cat#: 413470
Name: Darifenacin Free Base
CAS#: 133099-04-4 (free base)
Chemical Formula: C28H30N2O2
Exact Mass: 426.2307
Molecular Weight: 426.56
Elemental Analysis: C, 78.84; H, 7.09; N, 6.57; O, 7.50
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Related CAS #: 133099-04-4 (free base) 133099-07-7 (HBr)
Synonym: Darifenacin Free Base; Emselex; UK88525; UK 88525; UK-88525
IUPAC/Chemical Name: (S)-1-(2-(2,3-Dihydro-5-benzofuranyl)ethyl)-alpha,alpha-diphenyl-3-pyrrolidineacetamide
InChi Key: HXGBXQDTNZMWGS-RUZDIDTESA-N
InChi Code: InChI=1S/C28H30N2O2/c29-27(31)28(23-7-3-1-4-8-23,24-9-5-2-6-10-24)25-14-17-30(20-25)16-13-21-11-12-26-22(19-21)15-18-32-26/h1-12,19,25H,13-18,20H2,(H2,29,31)/t25-/m1/s1
SMILES Code: O=C(N)C(C1=CC=CC=C1)(C2=CC=CC=C2)[C@H]3CN(CCC4=CC=C(OCC5)C5=C4)CC3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: to be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 426.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. Darifenacin. 2017 Jul 7. PMID: 31644105.
2: Skerjanec A. The clinical pharmacokinetics of darifenacin. Clin Pharmacokinet. 2006;45(4):325-50. doi: 10.2165/00003088-200645040-00001. PMID: 16584282.
3: Seo MS, An JR, Jung HS, Kang M, Heo R, Han ET, Yang SR, Park H, Jung WK, Choi IW, Bae YM, Na SH, Park WS. Suppression of voltage-gated K+ channels by darifenacin in coronary arterial smooth muscle cells. Eur J Pharmacol. 2021 Jan 15;891:173707. doi: 10.1016/j.ejphar.2020.173707. Epub 2020 Oct 31. PMID: 33137332.
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6: Steers WD. Darifenacin: Pharmacology and clinical usage. Urol Clin North Am. 2006 Nov;33(4):475-82, viii. doi: 10.1016/j.ucl.2006.06.007. PMID: 17011383.
7: Haab F. Darifenacin in the treatment of overactive bladder. Drugs Today (Barc). 2005 Jul;41(7):441-52. doi: 10.1358/dot.2005.41.7.891719. PMID: 16193097.
8: Kissane LM, Martin KD, Meyer I, Richter HE. Effect of darifenacin on fecal incontinence in women with double incontinence. Int Urogynecol J. 2020 Jun 15:10.1007/s00192-020-04369-3. doi: 10.1007/s00192-020-04369-3. Epub ahead of print. PMID: 32542466; PMCID: PMC7736065.
9: Parsons M, Robinson D, Cardozo L. Darifenacin in the treatment of overactive bladder. Int J Clin Pract. 2005 Jul;59(7):831-8. doi: 10.1111/j.1368-5031.2005.00585.x. PMID: 15963212.
10: Dubinskaya A. Commentary: effect of darifenacin on fecal incontinence in women with double incontinence. Int Urogynecol J. 2020 Jun 17. doi: 10.1007/s00192-020-04387-1. Epub ahead of print. PMID: 32556847.
