WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 576142
Description: H-8208 is a benzimidazole dye that has been shown to intercalate into DNA.
MedKoo Cat#: 576142
Chemical Formula: C18H21N5
Exact Mass: 307.1797
Molecular Weight: 307.4
Elemental Analysis: C, 70.33; H, 6.89; N, 22.78
This product is not in stock, which may be available by custom synthesis.
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Synonym: H8208; H 8208; H-8208; Hoechst 8208
IUPAC/Chemical Name: Benzenamine, 4-(5-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl)-
InChi Key: GLVRIHLZMKQZSA-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H21N5/c1-22-8-10-23(11-9-22)15-6-7-16-17(12-15)21-18(20-16)13-2-4-14(19)5-3-13/h2-7,12H,8-11,19H2,1H3,(H,20,21)
SMILES Code: CN1CCN(CC1)c2ccc3[nH]c(nc3c2)c4ccc(N)cc4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: to be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 307.4 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1. Bardsley HJ, Sharples D, Grèzes JR. The binding of the benzimidazole dye H8208 to DNA and to polyinosinic-polycytidylic acid. J Pharm Pharmacol. 1987 Mar;39(3):212-4. doi: 10.1111/j.2042-7158.1987.tb06250.x. PMID: 2883286.
2. Hasegawa N, Kubota Y. Equilibrium and kinetic studies of the interaction of the benzimidazole dye Hoechst 8208 with nucleic acids. Nucleic Acids Symp Ser. 1993;(29):85-6. PMID: 8247805.
3. Nakamura H, Hifumi H, Kubota Y. The interaction of the benzimidazole dye Hoechst 8208 with nucleic acids. Nucleic Acids Symp Ser. 1990;(22):99-100. PMID: 2101927.