H-8208

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 576142

CAS#: 77572-84-0

Description: H-8208 is a benzimidazole dye that has been shown to intercalate into DNA.


Chemical Structure

img
H-8208
CAS# 77572-84-0

Theoretical Analysis

MedKoo Cat#: 576142
Name: H-8208
CAS#: 77572-84-0
Chemical Formula: C18H21N5
Exact Mass: 307.1797
Molecular Weight: 307.4
Elemental Analysis: C, 70.33; H, 6.89; N, 22.78

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: H8208; H 8208; H-8208; Hoechst 8208

IUPAC/Chemical Name: Benzenamine, 4-(5-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl)-

InChi Key: GLVRIHLZMKQZSA-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H21N5/c1-22-8-10-23(11-9-22)15-6-7-16-17(12-15)21-18(20-16)13-2-4-14(19)5-3-13/h2-7,12H,8-11,19H2,1H3,(H,20,21)

SMILES Code: CN1CCN(CC1)c2ccc3[nH]c(nc3c2)c4ccc(N)cc4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: to be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 307.4 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1. Bardsley HJ, Sharples D, Grèzes JR. The binding of the benzimidazole dye H8208 to DNA and to polyinosinic-polycytidylic acid. J Pharm Pharmacol. 1987 Mar;39(3):212-4. doi: 10.1111/j.2042-7158.1987.tb06250.x. PMID: 2883286.

2. Hasegawa N, Kubota Y. Equilibrium and kinetic studies of the interaction of the benzimidazole dye Hoechst 8208 with nucleic acids. Nucleic Acids Symp Ser. 1993;(29):85-6. PMID: 8247805.

3. Nakamura H, Hifumi H, Kubota Y. The interaction of the benzimidazole dye Hoechst 8208 with nucleic acids. Nucleic Acids Symp Ser. 1990;(22):99-100. PMID: 2101927.