LY-3475070
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 207152

CAS#: 2375815-63-5

Description: LY-3475070 is a potent and selective CD73 Inhibitor with IC50 of 28 nM. LY3475070 Alone or in Combination With Pembrolizumab is now under trials for patients with Advanced Cancer.


Chemical Structure

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LY-3475070
CAS# 2375815-63-5

Theoretical Analysis

MedKoo Cat#: 207152
Name: LY-3475070
CAS#: 2375815-63-5
Chemical Formula: C15H18N4O2
Exact Mass: 286.14
Molecular Weight: 286.335
Elemental Analysis: C, 62.92; H, 6.34; N, 19.57; O, 11.18

Price and Availability

Size Price Availability Quantity
100mg USD 2950 2 Weeks
200mg USD 4250 2 Weeks
500mg USD 6950 2 Weeks
1g USD 8950 2 Weeks
2g USD 14950 2 Weeks
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Synonym: LY-3475070; LY 3475070; LY3475070;

IUPAC/Chemical Name: 5-(5-((1S,2R)-2-isopropylcyclopropyl)-6-methylpyridazin-3-yl)pyrimidine-2,4(1H,3H)-dione

InChi Key: WHRUIISQCORGKK-KOLCDFICSA-N

InChi Code: InChI=1S/C15H18N4O2/c1-7(2)9-4-11(9)10-5-13(19-18-8(10)3)12-6-16-15(21)17-14(12)20/h5-7,9,11H,4H2,1-3H3,(H2,16,17,20,21)/t9-,11+/m1/s1

SMILES Code: O=C1NC(C(C2=NN=C(C)C([C@@H]3[C@@H](C(C)C)C3)=C2)=CN1)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Biological target: CD73-IN-3 is a potent CD73 inhibitor (IC50=7.3 nM in Calu6 human cell assay).
In vitro activity: TBD
In vivo activity: TBD

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 78.5 274.15
Ethanol 10.0 34.92

Preparing Stock Solutions

The following data is based on the product molecular weight 286.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

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