VH 032 amide-alkylC5-acid
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MedKoo CAT#: 464121

CAS#: 2162120-87-6

Description: VH 032 amide-alkylC5-acid is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC® research and development. It incorporates an E3 ligase ligand plus alkylC5 linker with terminal carboxylic acid ready for conjugation to a target protein ligand. It is part of a range of functionalized tool molecules for PROTAC R&D.

Chemical Structure

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VH 032 amide-alkylC5-acid
CAS# 2162120-87-6
Instruction

Theoretical Analysis

MedKoo Cat#: 464121
Name: VH 032 amide-alkylC5-acid
CAS#: 2162120-87-6
Chemical Formula: C29H40N4O6S
Exact Mass: 572.27
Molecular Weight: 572.721
Elemental Analysis: C, 60.82; H, 7.04; N, 9.78; O, 16.76; S, 5.60

Price and Availability

Size Price Availability Quantity
25mg USD 450 2 Weeks
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Synonym: VH 032 amide-alkylC5-acid; VH 032 amide alkylC5-acid; VH 032 amide-alkylC5 acid; VH 032 amide alkylC5 acid;

IUPAC/Chemical Name: 7-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-7-oxoheptanoic acid

InChi Key: LYAMSRXTXVKKIC-TVZXLZGTSA-N

InChi Code: InChI=1S/C29H40N4O6S/c1-18-25(40-17-31-18)20-12-10-19(11-13-20)15-30-27(38)22-14-21(34)16-33(22)28(39)26(29(2,3)4)32-23(35)8-6-5-7-9-24(36)37/h10-13,17,21-22,26,34H,5-9,14-16H2,1-4H3,(H,30,38)(H,32,35)(H,36,37)/t21-,22+,26-/m1/s1

SMILES Code: CC1=C(SC=N1)C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@@H](NC(CCCCCC(O)=O)=O)C(C)(C)C)=O)=O)C=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Soluble in DMSO 0.0 100.00

Preparing Stock Solutions

The following data is based on the product molecular weight 572.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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