11-cis Retinol

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 464107

CAS#: 22737-96-8

Description: 11-cis Retinol is an isomer of vitamin A. It is formed from vitamin A, via a trans-retinyl ester intermediate, by the enzyme RPE65 in the retinal pigment epithelium and then converted to 11-cis retinal as part of the visual cycle. 11-cis Retinol is an agonist of salamander and human red rod opsins expressed in COS cells and an inverse agonist of salamander red cone opsin, as well as human red and green cone opsins expressed in COS cells. It promotes pigment formation in cone, but not rod, photoreceptors.

Chemical Structure

11-cis Retinol
CAS# 22737-96-8

Theoretical Analysis

MedKoo Cat#: 464107
Name: 11-cis Retinol
CAS#: 22737-96-8
Chemical Formula: C20H30O
Exact Mass: 286.2297
Molecular Weight: 286.459
Elemental Analysis: C, 83.86; H, 10.56; O, 5.59

Price and Availability

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1.0mg USD 430.0 2 Weeks
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Synonym: 11-cis Retinol; 11 cis-Retinol; 11 cis Retinol; 11-cis-Retinol;

IUPAC/Chemical Name: (2E,4Z,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-ol


InChi Code: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 286.459 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Chatzistergiou V, Ambresin A, Borruat FX. Markedly Delayed Night Blindness Due to Vitamin A Insufficiency Secondary to Bowel Resection. Klin Monbl Augenheilkd. 2021 Feb 22. English. doi: 10.1055/a-1354-5816. Epub ahead of print. PMID: 33618384.

2: Jugha VT, Anchang-Kimbi JK, Anchang JA, Mbeng KA, Kimbi HK. Dietary Diversity and Its Contribution in the Etiology of Maternal Anemia in Conflict Hit Mount Cameroon Area: A Cross-Sectional Study. Front Nutr. 2021 Feb 4;7:625178. doi: 10.3389/fnut.2020.625178. PMID: 33614694; PMCID: PMC7889504.

3: Suo L, VanBuren C, Hovland ED, Kedishvili NY, Sundberg JP, Everts HB. Dietary Vitamin A Impacts Refractory Telogen. Front Cell Dev Biol. 2021 Feb 5;9:571474. doi: 10.3389/fcell.2021.571474. PMID: 33614636; PMCID: PMC7892905.

4: Muhammad Y, Kani YA, Iliya S, Muhammad JB, Binji A, El-Fulaty Ahmad A, Kabir MB, Umar Bindawa K, Ahmed A. Deficiency of antioxidants and increased oxidative stress in COVID-19 patients: A cross-sectional comparative study in Jigawa, Northwestern Nigeria. SAGE Open Med. 2021 Feb 1;9:2050312121991246. doi: 10.1177/2050312121991246. PMID: 33614035; PMCID: PMC7871282.

5: Doumani N, Maalouly J, Bou-Maroun E, Sok N, Cayot P, Tueni M. Iron intake among Lebanese women: sociodemographic factors, iron-rich dietary patterns, and preparation of hummus, a Mediterranean dish. Food Nutr Res. 2021 Jan 6;65. doi: 10.29219/fnr.v65.5556. PMID: 33613152; PMCID: PMC7869437.

6: Rahardjo F, Mardiana, A Taslim N. Formulating Diet for Transitional Feeding in Tuberculous Meningitis Patient during Hospital Care and through to Period of Home Healthcare. J Nutr Sci Vitaminol (Tokyo). 2020;66(Supplement):S41-S46. doi: 10.3177/jnsv.66.S41. PMID: 33612633.

7: Malahayati N, Muhammad K, Bakar J, Karim R. Fortification of Rice Noodles with Vitamin A: Quality, Sensory Evaluation, and Enhancement of Vitamin A Intakes. J Nutr Sci Vitaminol (Tokyo). 2020;66(Supplement):S179-S183. doi: 10.3177/jnsv.66.S179. PMID: 33612590.

8: Saragih B, Kristina F, Pradita, Candra KP, Emmawati A. Nutritional Value, Antioxidant Activity, Sensory Properties, and Glycemic Index of Cookies with the Addition of Cassava (Manihot utilissima) Leaf Flour. J Nutr Sci Vitaminol (Tokyo). 2020;66(Supplement):S162-S166. doi: 10.3177/jnsv.66.S162. PMID: 33612587.

9: Mosqueda-Solís A, Lafuente-Ibáñez de Mendoza I, Aguirre-Urizar JM, Mosqueda- Taylor A. Capsaicin intake and oral carcinogenesis: A systematic review. Med Oral Patol Oral Cir Bucal. 2021 Feb 20:24570. doi: 10.4317/medoral.24570. Epub ahead of print. PMID: 33609025.

10: Lata S, Bafna RK, Asif MI, Sachan A. Bilateral liquefactive corneal necrosis: a rare and devastating complication of vitamin A deficiency in the adult. BMJ Case Rep. 2021 Feb 19;14(2):e237343. doi: 10.1136/bcr-2020-237343. PMID: 33608333.

11: Shojadoost B, Yitbarek A, Alizadeh M, Kulkarni RR, Astill J, Boodhoo N, Sharif S. Centennial Review: Effects of vitamins A, D, E, and C on the chicken immune system. Poult Sci. 2021 Jan 7;100(4):100930. doi: 10.1016/j.psj.2020.12.027. Epub ahead of print. PMID: 33607314.

12: Esteban J, Sánchez I, Hamscher G, Miettinen HM, Korkalainen M, Viluksela M, Pohjanvirta R, Håkansson H. Role of aryl hydrocarbon receptor (AHR) in overall retinoid metabolism: Response comparisons to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure between wild-type and AHR knockout mice. Reprod Toxicol. 2021 Feb 16:S0890-6238(21)00042-3. doi: 10.1016/j.reprotox.2021.02.004. Epub ahead of print. PMID: 33607186.

13: Della Porta AL, Saikaly SK, Nyinawinyange D, De Benedetto A. Isotretinoin- Induced Inflammation of the Urethral Meatus. Dermatol Ther. 2021 Feb 18:e14898. doi: 10.1111/dth.14898. Epub ahead of print. PMID: 33605047.

14: Vettleson KL, Larson HJ, Mohamed MW, Grindeland CJ, Muzzy Williamson JD. Micronutrient Monitoring and Management in Parenteral Nutrition-Dependent Premature Neonates: A Case Series. J Pediatr Pharmacol Ther. 2021;26(2):200-204. doi: 10.5863/1551-6776-26.2.200. Epub 2021 Feb 15. PMID: 33603585; PMCID: PMC7887884.

15: Gicevic S, Mou Y, Bromage S, Fung TT, Willett W. Development of a Diet Quality Screener for Global Use: Evaluation in a Sample of US Women. J Acad Nutr Diet. 2021 Feb 15:S2212-2672(20)31577-X. doi: 10.1016/j.jand.2020.12.024. Epub ahead of print. PMID: 33602635.

16: Xiong K, Wang J, Zhang B, Xu L, Hu Y, Ma A. Vitamins A and D fail to protect against tuberculosis-drug-induced liver injury: A post hoc analysis of a previous randomized controlled trial. Nutrition. 2021 Jan 15;86:111155. doi: 10.1016/j.nut.2021.111155. Epub ahead of print. PMID: 33601121.

17: Bandara S, Thomas LD, Ramkumar S, Khadka N, Kiser PD, Golczak M, von Lintig J. The Structural and Biochemical Basis of Apocarotenoid Processing by β-Carotene Oxygenase-2. ACS Chem Biol. 2021 Feb 18. doi: 10.1021/acschembio.0c00832. Epub ahead of print. PMID: 33600157.

18: Ghosh-Jerath S, Kapoor R, Barman S, Singh G, Singh A, Downs S, Fanzo J. Traditional Food Environment and Factors Affecting Indigenous Food Consumption in Munda Tribal Community of Jharkhand, India. Front Nutr. 2021 Feb 1;7:600470. doi: 10.3389/fnut.2020.600470. PMID: 33598474; PMCID: PMC7882711.

19: Bighaghire R, Okidi L, Muggaga C, Ongeng D. Traditional vegetable preservation technologies practiced in Acholi subregion of Uganda improves mineral bioavailability but impacts negatively on the contribution of vegetables to household needs for micronutrients. Food Sci Nutr. 2021 Jan 7;9(2):589-604. doi: 10.1002/fsn3.1931. PMID: 33598145; PMCID: PMC7866598.

20: Katagiri N, Hitomi H, Mae SI, Kotaka M, Lei L, Yamamoto T, Nishiyama A, Osafune K. Retinoic acid regulates erythropoietin production cooperatively with hypoxia-inducible factors in human iPSC-derived erythropoietin-producing cells. Sci Rep. 2021 Feb 16;11(1):3936. doi: 10.1038/s41598-021-83431-6. PMID: 33594180; PMCID: PMC7887226.