WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 555915
CAS#: 2561476-24-0
Description: EMAC10101d is a potent and selective inhibitor of Carbonic Anhydrase Isoform toward hCA II with an inhibitory activity in the low nanomolar range.
MedKoo Cat#: 555915
Name: EMAC10101d
CAS#: 2561476-24-0
Chemical Formula: C17H15Cl2N3O2S2
Exact Mass: 426.9983
Molecular Weight: 428.346
Elemental Analysis: C, 47.67; H, 3.53; Cl, 16.55; N, 9.81; O, 7.47; S, 14.97
EMAC10101d is in stock.
Synonym: EMAC10101d; EMAC-10101d; EMAC 10101d
IUPAC/Chemical Name: (Z)-4-((4-(2,4-dichlorophenyl)-3-ethylthiazol-2(3H)-ylidene)amino)benzenesulfonamide
InChi Key: OEGLVUQKHJHUEU-FXBPSFAMSA-N
InChi Code: InChI=1S/C17H15Cl2N3O2S2/c1-2-22-16(14-8-3-11(18)9-15(14)19)10-25-17(22)21-12-4-6-13(7-5-12)26(20,23)24/h3-10H,2H2,1H3,(H2,20,23,24)/b21-17-
SMILES Code: O=S(C1=CC=C(/N=C2SC=C(C3=CC=C(Cl)C=C3Cl)N\2CC)C=C1)(N)=O
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
Soluble in DMSO | 100.0 |
The following data is based on the product molecular weight 428.346 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Meleddu R, Distinto S, Cottiglia F, Angius R, Caboni P, Angeli A, Melis C, Deplano S, Alcaro S, Ortuso F, Supuran CT, Maccioni E. New Dihydrothiazole Benzensulfonamides: Looking for Selectivity toward Carbonic Anhydrase Isoforms I, II, IX, and XII. ACS Med Chem Lett. 2020 Feb 13;11(5):852-856. doi: 10.1021/acsmedchemlett.9b00644. PMID: 32435395; PMCID: PMC7236253.