EMAC10101d
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555915

CAS#: 2561476-24-0

Description: EMAC10101d is a potent and selective inhibitor of Carbonic Anhydrase Isoform toward hCA II with an inhibitory activity in the low nanomolar range.


Chemical Structure

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EMAC10101d
CAS# 2561476-24-0

Theoretical Analysis

MedKoo Cat#: 555915
Name: EMAC10101d
CAS#: 2561476-24-0
Chemical Formula: C17H15Cl2N3O2S2
Exact Mass: 426.9983
Molecular Weight: 428.346
Elemental Analysis: C, 47.67; H, 3.53; Cl, 16.55; N, 9.81; O, 7.47; S, 14.97

Price and Availability

Size Price Availability Quantity
50.0mg USD 550.0 2 Weeks
100.0mg USD 950.0 2 Weeks
200.0mg USD 1650.0 2 Weeks
500.0mg USD 2650.0 2 Weeks
1.0g USD 3450.0 2 Weeks
2.0g USD 5650.0 2 Weeks
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Synonym: EMAC10101d; EMAC-10101d; EMAC 10101d

IUPAC/Chemical Name: (Z)-4-((4-(2,4-dichlorophenyl)-3-ethylthiazol-2(3H)-ylidene)amino)benzenesulfonamide

InChi Key: OEGLVUQKHJHUEU-FXBPSFAMSA-N

InChi Code: InChI=1S/C17H15Cl2N3O2S2/c1-2-22-16(14-8-3-11(18)9-15(14)19)10-25-17(22)21-12-4-6-13(7-5-12)26(20,23)24/h3-10H,2H2,1H3,(H2,20,23,24)/b21-17-

SMILES Code: O=S(C1=CC=C(/N=C2SC=C(C3=CC=C(Cl)C=C3Cl)N\2CC)C=C1)(N)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 428.346 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Meleddu R, Distinto S, Cottiglia F, Angius R, Caboni P, Angeli A, Melis C, Deplano S, Alcaro S, Ortuso F, Supuran CT, Maccioni E. New Dihydrothiazole Benzensulfonamides: Looking for Selectivity toward Carbonic Anhydrase Isoforms I, II, IX, and XII. ACS Med Chem Lett. 2020 Feb 13;11(5):852-856. doi: 10.1021/acsmedchemlett.9b00644. PMID: 32435395; PMCID: PMC7236253.