DKN14009
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555914

CAS#: 566914-00-9

Description: DKN14009, also known as IL-1R antagonist, is a peptide mimic of the myeloid differentiation primary response gene 88 (MyD88) that changes the interaction of MyD88 and IL-1 receptor type I (IL-1RI). This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).


Chemical Structure

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DKN14009
CAS# 566914-00-9

Theoretical Analysis

MedKoo Cat#: 555914
Name: DKN14009
CAS#: 566914-00-9
Chemical Formula: C18H26N2O2
Exact Mass: 302.20
Molecular Weight: 302.418
Elemental Analysis: C, 71.49; H, 8.67; N, 9.26; O, 10.58

Price and Availability

Size Price Availability Quantity
100mg USD 850 2 Weeks
200mg USD 1450 2 Weeks
500mg USD 2050 2 Weeks
1g USD 2950 2 Weeks
2g USD 5150 2 Weeks
Bulk inquiry

Synonym: IL-1R Antagonist; DKN14009; DKN 14009; DKN-14009;

IUPAC/Chemical Name: N-[(1S)-2-methyl-1-(1-pyrrolidinylcarbonyl)propyl]-benzenepropanamide

InChi Key: DAZSWUUAFHBCGE-KRWDZBQOSA-N

InChi Code: InChI=1S/C18H26N2O2/c1-14(2)17(18(22)20-12-6-7-13-20)19-16(21)11-10-15-8-4-3-5-9-15/h3-5,8-9,14,17H,6-7,10-13H2,1-2H3,(H,19,21)/t17-/m0/s1

SMILES Code: O=C(N[C@H](C(N1CCCC1)=O)C(C)C)CCC2=CC=CC=C2

Appearance: a solution in ethanol (100mg/mL)

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Biological target: TLR1 (DKN14009) is a low molecular weight, cell-penetrating Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimic. TLR1 inhibits IL-1 receptor-mediated responses.
In vitro activity: TBD
In vivo activity: TBD

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Soluble in DMSO 0.0 100.00

Preparing Stock Solutions

The following data is based on the product molecular weight 302.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

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