WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 464049
CAS#: unknown
Description: p53 Reactivator C85 is a novel reactivator of mutant p53, functioning as a zinc metallochaperone (ZMC) with diminished copper binding that functions as a chemotherapy and radiation sensitizer.
MedKoo Cat#: 464049
Name: p53 Reactivator C85
CAS#: unknown
Chemical Formula: C20H22F2N6
Exact Mass: 384.1874
Molecular Weight: 384.4348
Elemental Analysis: C, 62.49; H, 5.77; F, 9.88; N, 21.86
This product is not in stock, which may be available by custom synthesis.
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Synonym: p53 Reactivator C85; p53-Reactivator-C85;
IUPAC/Chemical Name: (E)-1-(2-(3,3-difluoropyrrolidin-1-yl)ethyl)-2-(2-(1-(pyridin-2-yl)ethylidene)hydrazinyl)-1H-benzo[d]imidazole
InChi Key: VGIXWWLJCGSRBH-MFKUBSTISA-N
InChi Code: InChI=1S/C20H22F2N6/c1-15(16-6-4-5-10-23-16)25-26-19-24-17-7-2-3-8-18(17)28(19)13-12-27-11-9-20(21,22)14-27/h2-8,10H,9,11-14H2,1H3,(H,24,26)/b25-15+
SMILES Code: C/C(C1=NC=CC=C1)=N\NC2=NC3=CC=CC=C3N2CCN4CC(F)(F)CC4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 384.4348 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Gilleran JA, Yu X, Blayney AJ, Bencivenga AF, Na B, Augeri DJ, Blanden AR, Kimball SD, Loh SN, Roberge JY, Carpizo DR. Benzothiazolyl and Benzoxazolyl Hydrazones Function as Zinc Metallochaperones to Reactivate Mutant p53. J Med Chem. 2021 Feb 4. doi: 10.1021/acs.jmedchem.0c01360. Epub ahead of print. PMID: 33538587.
