Varioxepine A
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MedKoo CAT#: 464016

CAS#: 1623451-72-8

Description: Varioxepine A is a fungal metabolite originally isolated from P. variotii. It is active against the plant pathogenic fungus F. graminearum.


Chemical Structure

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Varioxepine A
CAS# 1623451-72-8

Theoretical Analysis

MedKoo Cat#: 464016
Name: Varioxepine A
CAS#: 1623451-72-8
Chemical Formula: C26H29N3O5
Exact Mass: 463.2107
Molecular Weight: 463.534
Elemental Analysis: C, 67.37; H, 6.31; N, 9.07; O, 17.26

Price and Availability

Size Price Availability Quantity
1.0mg USD 610.0 2 Weeks
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Synonym: Varioxepine A; Varioxepine-A;

IUPAC/Chemical Name: (3R,5aR,15S,16aS)-15-benzyl-12-isopropyl-2,2-dimethyl-3,4-dihydro-2H,13H-3,16a-epoxy[1,4]dioxepino[2,3-e]oxepino[2,3-d]pyrazino[1,2-a]pyrimidin-14(15H)-one

InChi Key: PZRCCRWGGJKTKC-GZLQHJCCSA-N

InChi Code: InChI=1S/C26H29N3O5/c1-16(2)20-21-28-23-25(12-8-9-13-31-23)26(33-19(15-32-25)24(3,4)34-26)29(21)18(22(30)27-20)14-17-10-6-5-7-11-17/h5-13,16,18-19H,14-15H2,1-4H3,(H,27,30)/t18-,19+,25+,26-/m0/s1

SMILES Code: CC(C(NC1=O)=C2N=C3OC=CC=C[C@@]34OC[C@@H]5C(O[C@@]4(N2[C@H]1CC6=CC=CC=C6)O5)(C)C)C

Appearance: Solid powder

Purity: >95% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 463.534 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Wu Q, Wu C, Long H, Chen R, Liu D, Proksch P, Guo P, Lin W. Varioxiranols A-G and 19-O-Methyl-22-methoxypre-shamixanthone, PKS and Hybrid PKS-Derived Metabolites from a Sponge-Associated Emericella variecolor Fungus. J Nat Prod. 2015 Oct 23;78(10):2461-70. doi: 10.1021/acs.jnatprod.5b00578. Epub 2015 Sep 22. PMID: 26394166.

2: Zhang P, Mándi A, Li XM, Du FY, Wang JN, Li X, Kurtán T, Wang BG. Varioxepine A, a 3H-oxepine-containing alkaloid with a new oxa-cage from the marine algal- derived endophytic fungus Paecilomyces variotii. Org Lett. 2014 Sep 19;16(18):4834-7. doi: 10.1021/ol502329k. Epub 2014 Aug 28. PMID: 25167167.