WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 464016
Description: Varioxepine A is a fungal metabolite originally isolated from P. variotii. It is active against the plant pathogenic fungus F. graminearum.
MedKoo Cat#: 464016
Name: Varioxepine A
Chemical Formula: C26H29N3O5
Exact Mass: 463.2107
Molecular Weight: 463.534
Elemental Analysis: C, 67.37; H, 6.31; N, 9.07; O, 17.26
Synonym: Varioxepine A; Varioxepine-A;
IUPAC/Chemical Name: (3R,5aR,15S,16aS)-15-benzyl-12-isopropyl-2,2-dimethyl-3,4-dihydro-2H,13H-3,16a-epoxy[1,4]dioxepino[2,3-e]oxepino[2,3-d]pyrazino[1,2-a]pyrimidin-14(15H)-one
InChi Key: PZRCCRWGGJKTKC-GZLQHJCCSA-N
InChi Code: InChI=1S/C26H29N3O5/c1-16(2)20-21-28-23-25(12-8-9-13-31-23)26(33-19(15-32-25)24(3,4)34-26)29(21)18(22(30)27-20)14-17-10-6-5-7-11-17/h5-13,16,18-19H,14-15H2,1-4H3,(H,27,30)/t18-,19+,25+,26-/m0/s1
SMILES Code: CC(C(NC1=O)=C2N=C3OC=CC=C[C@@]34OC[C@@H]5C(O[C@@]4(N2[C@H]1CC6=CC=CC=C6)O5)(C)C)C
Appearance: Solid powder
Purity: >95% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 463.534 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Wu Q, Wu C, Long H, Chen R, Liu D, Proksch P, Guo P, Lin W. Varioxiranols A-G and 19-O-Methyl-22-methoxypre-shamixanthone, PKS and Hybrid PKS-Derived Metabolites from a Sponge-Associated Emericella variecolor Fungus. J Nat Prod. 2015 Oct 23;78(10):2461-70. doi: 10.1021/acs.jnatprod.5b00578. Epub 2015 Sep 22. PMID: 26394166.
2: Zhang P, Mándi A, Li XM, Du FY, Wang JN, Li X, Kurtán T, Wang BG. Varioxepine A, a 3H-oxepine-containing alkaloid with a new oxa-cage from the marine algal- derived endophytic fungus Paecilomyces variotii. Org Lett. 2014 Sep 19;16(18):4834-7. doi: 10.1021/ol502329k. Epub 2014 Aug 28. PMID: 25167167.