Thimerosal | CAS# 54-64-8 | ethylmercury-sulfidobenzoate

Thimerosal
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 413239

CAS#: 54-64-8

Description: Thimerosal is an ethylmercury-sulfidobenzoate that has been used as a preservative in VACCINES; ANTIVENINS; and OINTMENTS. It was formerly used as a topical antiseptic. It degrades to ethylmercury and thiosalicylate.

Chemical Structure

Thimerosal

CAS# 54-64-8

Instruction

Theoretical Analysis

MedKoo Cat#: 413239
Name: Thimerosal
CAS#: 54-64-8
Chemical Formula: C9H9HgNaO2S
Exact Mass: 405.99
Molecular Weight: 404.810
Elemental Analysis: C, 26.70; H, 2.24; Hg, 49.55; Na, 5.68; O, 7.90; S, 7.92

Price and Availability

Size	Price	Availability
10g	USD 318	2 Weeks
25g	USD 559	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Thimerosal; HSDB7151; HSDB-7151; HSDB 7151

IUPAC/Chemical Name: sodium ((2-carboxylatophenyl)thio)(ethyl)mercury

InChi Key: RTKIYNMVFMVABJ-UHFFFAOYSA-L

InChi Code: InChI=1S/C7H6O2S.C2H5.Hg.Na/c8-7(9)5-3-1-2-4-6(5)10;1-2;;/h1-4,10H,(H,8,9);1H2,2H3;;/q;;2*+1/p-2

SMILES Code: CC[Hg]Sc1c(C([O-])=O)cccc1.[Na+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	Soluble in DMSO	0.0	100.00

Preparing Stock Solutions

The following data is based on the product molecular weight 404.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Dórea JG. Low-dose Thimerosal (ethyl-mercury) is still used in infants` vaccines: Should we be concerned with this form of exposure? J Trace Elem Med Biol. 2018 Sep;49:134-139. doi: 10.1016/j.jtemb.2018.05.010. Epub 2018 May 17. PMID: 29895363.

2: Dórea JG, Farina M, Rocha JB. Toxicity of ethylmercury (and Thimerosal): a comparison with methylmercury. J Appl Toxicol. 2013 Aug;33(8):700-11. doi: 10.1002/jat.2855. Epub 2013 Feb 11. PMID: 23401210.

3: Hooker B, Kern J, Geier D, Haley B, Sykes L, King P, Geier M. Methodological issues and evidence of malfeasance in research purporting to show thimerosal in vaccines is safe. Biomed Res Int. 2014;2014:247218. doi: 10.1155/2014/247218. Epub 2014 Jun 4. PMID: 24995277; PMCID: PMC4065774.

4: Uno Y, Uchiyama T, Kurosawa M, Aleksic B, Ozaki N. Early exposure to the combined measles-mumps-rubella vaccine and thimerosal-containing vaccines and risk of autism spectrum disorder. Vaccine. 2015 May 15;33(21):2511-6. doi: 10.1016/j.vaccine.2014.12.036. Epub 2015 Jan 3. PMID: 25562790.

5: Peng B, Che D, Hao Y, Zheng Y, Liu R, Qian Y, Cao J, Wang J, Zhang Y, He L, Geng S. Thimerosal induces skin pseudo-allergic reaction via Mas-related G-protein coupled receptor B2. J Dermatol Sci. 2019 Sep;95(3):99-106. doi: 10.1016/j.jdermsci.2019.07.007. Epub 2019 Jul 24. PMID: 31558225.

6: Nelson KB, Bauman ML. Thimerosal and autism? Pediatrics. 2003 Mar;111(3):674-9. doi: 10.1542/peds.111.3.674. PMID: 12612255.

7: Dórea JG. Low-dose Thimerosal in pediatric vaccines: Adverse effects in perspective. Environ Res. 2017 Jan;152:280-293. doi: 10.1016/j.envres.2016.10.028. Epub 2016 Nov 3. PMID: 27816865.

8: Sykes LK, Geier DA, King PG, Kern JK, Haley BE, Chaigneau CG, Megson MN, Love JM, Reeves RE, Geier MR. Thimerosal as discrimination: vaccine disparity in the UN Minamata Convention on mercury. Indian J Med Ethics. 2014 Oct- Dec;11(4):206-18. doi: 10.20529/IJME.2014.054. Epub 2014 Apr 11. PMID: 25101548.

9: Geier DA, King PG, Hooker BS, Dórea JG, Kern JK, Sykes LK, Geier MR. Thimerosal: clinical, epidemiologic and biochemical studies. Clin Chim Acta. 2015 Apr 15;444:212-20. doi: 10.1016/j.cca.2015.02.030. Epub 2015 Feb 21. PMID: 25708367.

10: Mádi A. Being on the track of thimerosal. Review. Acta Microbiol Immunol Hung. 2005;52(1):95-103. doi: 10.1556/AMicr.52.2005.1.5. PMID: 15957237.

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