Acesulfame potassium salt

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 463975

CAS#: 55589-62-3

Description: Acesulfame is a non-caloric sweetener used as a sugar alternative that is not metabolized by humans. Excreted acesulfame has been found in wastewater and is considered a pollutant.

Chemical Structure

Acesulfame potassium salt
CAS# 55589-62-3

Theoretical Analysis

MedKoo Cat#: 463975
Name: Acesulfame potassium salt
CAS#: 55589-62-3
Chemical Formula: C4H4KNO4S
Exact Mass:
Molecular Weight: 201.2373
Elemental Analysis: C, 23.87; H, 2.00; K, 19.43; N, 6.96; O, 31.80; S, 15.93

Price and Availability

Size Price Availability Quantity
25.0g USD 350.0 2 Weeks
50.0g USD 550.0 2 Weeks
100.0g USD 950.0 2 Weeks
250.0g USD 1950.0 2 Weeks
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Synonym: Acesulfame potassium salt; E950; E 950; E-950;

IUPAC/Chemical Name: potassium 6-methyl-4-oxo-4H-1,2,3-oxathiazin-3-ide 2,2-dioxide


InChi Code: InChI=1S/C4H5NO4S.K/c1-3-2-4(6)5-10(7,8)9-3;/h2H,1H3,(H,5,6);/q;+1/p-1

SMILES Code: O=C1C=C(OS(=O)([N-]1)=O)C.[K+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 201.2373 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Pittman DW, Dong G, Brantly AM, He L, Nelson TS, Kogan S, Powell J, McCluskey LP. Behavioral and neurophysiological taste responses to sweet and salt are diminished in a model of subclinical intestinal inflammation. Sci Rep. 2020 Oct 19;10(1):17611. doi: 10.1038/s41598-020-74632-6. PMID: 33077838; PMCID: PMC7573616.

2: Zhao X, Li Q, Wang C, Hu S, He X, Sun CC. Simultaneous taste-masking and oral bioavailability enhancement of Ligustrazine by forming sweet salts. Int J Pharm. 2020 Mar 15;577:119089. doi: 10.1016/j.ijpharm.2020.119089. Epub 2020 Jan 27. PMID: 32001292.

3: Zhang M, Yang X, Xu W, Cai X, Wang M, Xu Y, Yu P, Zhang J, Zheng Y, Chen J, Yang J, Zhu X. Evaluation of the effects of three sulfa sweeteners on the lifespan and intestinal fat deposition in C. elegans. Food Res Int. 2019 Aug;122:66-76. doi: 10.1016/j.foodres.2019.03.028. Epub 2019 Mar 13. PMID: 31229125.

4: Paul S, Wang C, Wang K, Sun CC. Reduced Punch Sticking Propensity of Acesulfame by Salt Formation: Role of Crystal Mechanical Property and Surface Chemistry. Mol Pharm. 2019 Jun 3;16(6):2700-2707. doi: 10.1021/acs.molpharmaceut.9b00247. Epub 2019 Apr 26. PMID: 30973740.

5: Wang C, Hu S, Sun CC. Expedited development of a high dose orally disintegrating metformin tablet enabled by sweet salt formation with acesulfame. Int J Pharm. 2017 Oct 30;532(1):435-443. doi: 10.1016/j.ijpharm.2017.08.100. Epub 2017 Aug 26. PMID: 28844896.

6: Wang C, Hu S, Sun CC. Expedited Development of Diphenhydramine Orally Disintegrating Tablet through Integrated Crystal and Particle Engineering. Mol Pharm. 2017 Oct 2;14(10):3399-3408. doi: 10.1021/acs.molpharmaceut.7b00423. Epub 2017 Sep 6. PMID: 28825961.

7: Tahara S, Yamamoto S, Yamajima Y, Miyakawa H, Uematsu Y, Monma K. [A Rapid Dialysis Method for Analysis of Artificial Sweeteners in Foods (2nd Report)]. Shokuhin Eiseigaku Zasshi. 2017;58(3):124-131. Japanese. doi: 10.3358/shokueishi.58.124. PMID: 28690302.

8: Zarejousheghani M, Schrader S, Möder M, Lorenz P, Borsdorf H. Ion-exchange molecularly imprinted polymer for the extraction of negatively charged acesulfame from wastewater samples. J Chromatogr A. 2015 Sep 11;1411:23-33. doi: 10.1016/j.chroma.2015.07.107. Epub 2015 Aug 1. PMID: 26256920.

9: Ren W, Lewandowski BC, Watson J, Aihara E, Iwatsuki K, Bachmanov AA, Margolskee RF, Jiang P. Single Lgr5- or Lgr6-expressing taste stem/progenitor cells generate taste bud cells ex vivo. Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16401-6. doi: 10.1073/pnas.1409064111. Epub 2014 Nov 3. PMID: 25368147; PMCID: PMC4246268.

10: Dasgupta J, Elliott RA, Doshani A, Tincello DG. Enhancement of rat bladder contraction by artificial sweeteners via increased extracellular Ca2+ influx. Toxicol Appl Pharmacol. 2006 Dec 1;217(2):216-24. doi: 10.1016/j.taap.2006.09.004. Epub 2006 Sep 12. PMID: 17046038.