Thidiazuron
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MedKoo CAT#: 463946

CAS#: 51707-55-2

Description: Thidiazuron is a highly efficient bioregulator of plant morphogenesis in the tissue culture technique, inducing diverse responses ranging from induction of callus to embryogenesis or organogenesis, acting through modulation of the endogenous plant growth regulators, modification in cell membranes, energy levels, nutrient uptake, or nutrient assimilation.


Chemical Structure

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Thidiazuron
CAS# 51707-55-2

Theoretical Analysis

MedKoo Cat#: 463946
Name: Thidiazuron
CAS#: 51707-55-2
Chemical Formula: C9H8N4OS
Exact Mass: 220.04
Molecular Weight: 220.250
Elemental Analysis: C, 49.08; H, 3.66; N, 25.44; O, 7.26; S, 14.56

Price and Availability

Size Price Availability Quantity
1g USD 350 2 Weeks
2g USD 550 2 Weeks
5g USD 950 2 Weeks
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Synonym: Thidiazuron; TDZ; Defolit; Dropp;

IUPAC/Chemical Name: 1-phenyl-3-(1,2,3-thiadiazol-5-yl)urea

InChi Key: HFCYZXMHUIHAQI-UHFFFAOYSA-N

InChi Code: InChI=1S/C9H8N4OS/c14-9(12-8-6-10-13-15-8)11-7-4-2-1-3-5-7/h1-6H,(H2,11,12,14)

SMILES Code: O=C(NC1=CN=NS1)NC2=CC=CC=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:

Preparing Stock Solutions

The following data is based on the product molecular weight 220.250000000000000000000000000000 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Taha RA, Allam MA, Hassan SAM, Bakr BMM, Hassan MM. Thidiazuron-induced direct organogenesis from immature inflorescence of three date palm cultivars. J Genet Eng Biotechnol. 2021 Jan 20;19(1):14. doi: 10.1186/s43141-021-00115-4. PMID: 33474639; PMCID: PMC7817752. 2. Sherif NA, Senthil Kumar T, Rao MV. DNA barcoding and genetic fidelity assessment of micropropagated Aenhenrya rotundifolia (Blatt.) C.S. Kumar and F.N. Rasm.: a critically endangered jewel orchid. Physiol Mol Biol Plants. 2020 Dec;26(12):2391-2405. doi: 10.1007/s12298-020-00917-9. Epub 2020 Dec 24. PMID: 33424154; PMCID: PMC7772124. 3. Chung HH, Ouyang HY. Use of Thidiazuron for High-Frequency Callus Induction and Organogenesis of Wild Strawberry (Fragaria vesca). Plants (Basel). 2020 Dec 30;10(1):67. doi: 10.3390/plants10010067. PMID: 33396927; PMCID: PMC7823688. 4. Jin D, Xu Y, Gui H, Zhang H, Dong Q, Sikder RK, Wang X, Yang G, Song M. Evaluation of Cotton (Gossypium hirsutum L.) Leaf Abscission Sensitivity Triggered by Thidiazuron through Membership Function Value. Plants (Basel). 2020 Dec 28;10(1):49. doi: 10.3390/plants10010049. PMID: 33379380; PMCID: PMC7823538. 5. van Voorthuizen MJ, Nisler J, Song J, Spíchal L, Jameson PE. Targeting Cytokinin Homeostasis in Rapid Cycling Brassica rapa with Plant Growth Regulators INCYDE and TD-K. Plants (Basel). 2020 Dec 25;10(1):39. doi: 10.3390/plants10010039. PMID: 33375745; PMCID: PMC7824111. 6. Ioannidis K, Dadiotis E, Mitsis V, Melliou E, Magiatis P. Biotechnological Approaches on Two High CBD and CBG Cannabis sativa L. (Cannabaceae) Varieties: In Vitro Regeneration and Phytochemical Consistency Evaluation of Micropropagated Plants Using Quantitative 1H-NMR. Molecules. 2020 Dec 15;25(24):5928. doi: 10.3390/molecules25245928. PMID: 33333745; PMCID: PMC7765244. 7. Schuchovski C, Sant'Anna-Santos BF, Marra RC, Biasi LA. Morphological and anatomical insights into de novo shoot organogenesis of in vitro 'Delite' rabbiteye blueberries. Heliyon. 2020 Nov 13;6(11):e05468. doi: 10.1016/j.heliyon.2020.e05468. PMID: 33251355; PMCID: PMC7677692. 8. Song K, Sivanesan I, Ak G, Zengin G, Cziáky Z, Jekő J, Rengasamy KR, Lee ON, Kim DH. Screening of Bioactive Metabolites and Biological Activities of Calli, Shoots, and Seedlings of Mertensia maritima (L.) Gray. Plants (Basel). 2020 Nov 12;9(11):1551. doi: 10.3390/plants9111551. PMID: 33198181; PMCID: PMC7697918. 9. Lee ON, Ak G, Zengin G, Cziáky Z, Jekő J, Rengasamy KRR, Park HY, Kim DH, Sivanesan I. Phytochemical Composition, Antioxidant Capacity, and Enzyme Inhibitory Activity in Callus, Somaclonal Variant, and Normal Green Shoot Tissues of Catharanthus roseus (L) G. Don. Molecules. 2020 Oct 26;25(21):4945. doi: 10.3390/molecules25214945. PMID: 33114628; PMCID: PMC7663286. 10. Ibrahim HI, Ismail MB, Ammar RB, Ahmed E. Thidiazuron suppresses breast cancer progression via targeting miR-132 and miR-202-5p/PTEN axis mediated dysregulation of PI3K/AKT signaling pathway. Biochem Cell Biol. 2020 Oct 24. doi: 10.1139/bcb-2020-0377. Epub ahead of print. PMID: 33103467. 11. Liu Y, Yang X, Zhao Y, Yang Y, Liu Z. An effective method for Agrobacterium tumefaciens-mediated transformation of Jatropha curcas L. using cotyledon explants. Bioengineered. 2020 Dec;11(1):1146-1158. doi: 10.1080/21655979.2020.1831363. PMID: 33070678. 12. Miguel S, Michel C, Biteau F, Hehn A, Bourgaud F. In vitro plant regeneration and Agrobacterium-mediated genetic transformation of a carnivorous plant, Nepenthes mirabilis. Sci Rep. 2020 Oct 15;10(1):17482. doi: 10.1038/s41598-020-74108-7. PMID: 33060701; PMCID: PMC7566609. 13. Sessou AF, Kahia JW, Houngue JA, Ateka EM, Dadjo C, Ahanhanzo C. In vitro propagation of three mosaic disease resistant cassava cultivars. BMC Biotechnol. 2020 Sep 29;20(1):51. doi: 10.1186/s12896-020-00645-8. PMID: 32993601; PMCID: PMC7526170. 14. Restrepo-Osorio C, Gil-Correal A, Chamorro-Gutiérrez L, Ramírez-Ríos V, Álvarez JC, Villanueva-Mejía D. Efficient direct shoot organogenesis and genetic stability in micropropagated sacha inchi (Plukenetia volubilis L.). BMC Res Notes. 2020 Sep 3;13(1):414. doi: 10.1186/s13104-020-05257-1. PMID: 32883361; PMCID: PMC7650214. 15. Erland LAE, Giebelhaus RT, Victor JMR, Murch SJ, Saxena PK. The Morphoregulatory Role of Thidiazuron: Metabolomics-Guided Hypothesis Generation for Mechanisms of Activity. Biomolecules. 2020 Aug 28;10(9):1253. doi: 10.3390/biom10091253. PMID: 32872300; PMCID: PMC7564436. 16. Yao R, Wang Y. An advanced protocol for the establishment of plantlets originating from somatic embryos in Pinus massoniana. 3 Biotech. 2020 Sep;10(9):394. doi: 10.1007/s13205-020-02385-0. Epub 2020 Aug 17. PMID: 32850284; PMCID: PMC7431525. 17. Thu HTM, Naing AH, Jeong HY, Kim CK. Regeneration of Genetically Stable Plants from in Vitro Vitrified Leaves of Different Carnation Cultivars. Plants (Basel). 2020 Jul 28;9(8):950. doi: 10.3390/plants9080950. PMID: 32731438; PMCID: PMC7465169. 18. Yang Y, Zhang Y, Gou C, Wu W, Wang H, Zeng Q. Solar photocatalytic degradation of thidiazuron in Yangtze River water matrix by Ag/AgCl-AC at circumneutral condition. Environ Sci Pollut Res Int. 2020 Nov;27(32):40857-40869. doi: 10.1007/s11356-020-09946-z. Epub 2020 Jul 16. PMID: 32677010. 19. Liang H, Xiong Y, Guo B, Yan H, Jian S, Ren H, Zhang X, Li Y, Zeng S, Wu K, Zheng F, Teixeira da Silva JA, Xiong Y, Ma G. Shoot organogenesis and somatic embryogenesis from leaf and root explants of Scaevola sericea. Sci Rep. 2020 Jul 9;10(1):11343. doi: 10.1038/s41598-020-68084-1. PMID: 32647162; PMCID: PMC7347615.