Gevotroline hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 575862

CAS#: 112243-58-0

Description: Gevotroline hydrochloride is a sigma receptor ligand that has been shown to elevate corticosterone levels in plasma.

Chemical Structure

Gevotroline hydrochloride
CAS# 112243-58-0

Theoretical Analysis

MedKoo Cat#: 575862
Name: Gevotroline hydrochloride
CAS#: 112243-58-0
Chemical Formula: C19H21ClFN3
Exact Mass: 345.1408
Molecular Weight: 345.85
Elemental Analysis: C, 65.99; H, 6.12; Cl, 10.25; F, 5.49; N, 12.15

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Gevotroline hydrochloride; Gevotroline HCl; WY-47384; WY47384; WY 47384

IUPAC/Chemical Name: 1H-Pyrido(4,3-b)indole, 8-fluoro-2,3,4,5-tetrahydro-2-(3-(3-pyridinyl)propyl)-, monohydrochloride


InChi Code: InChI=1S/C19H20FN3.ClH/c20-15-5-6-18-16(11-15)17-13-23(10-7-19(17)22-18)9-2-4-14-3-1-8-21-12-14;/h1,3,5-6,8,11-12,22H,2,4,7,9-10,13H2;1H

SMILES Code: Cl.Fc1ccc2[nH]c3CCN(CCCc4cccnc4)Cc3c2c1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 345.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Djeni TN, Kouame KH, Ake FDM, Amoikon LST, Dje MK, Jeyaram K. Microbial Diversity and Metabolite Profiles of Palm Wine Produced From Three Different Palm Tree Species in Côte d'Ivoire. Sci Rep. 2020 Feb 3;10(1):1715. doi: 10.1038/s41598-020-58587-2. PMID: 32015447; PMCID: PMC6997158.

2. Matheson GK, Guthrie D, Bauer C, Knowles A, White G, Ruston C. Sigma receptor ligands alter concentrations of corticosterone in plasma in the rat. Neuropharmacology. 1991 Jan;30(1):79-87. doi: 10.1016/0028-3908(91)90046-e. PMID: 1675451.