Gefapixant citrate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 575847

CAS#: 2310299-91-1 (citrate)

Description: Gefapixant citrate is a P2X3 antagonist currently studied for use in the treatment of disorders associated with purinergic receptor activation.

Chemical Structure

Gefapixant citrate
CAS# 2310299-91-1 (citrate)

Theoretical Analysis

MedKoo Cat#: 575847
Name: Gefapixant citrate
CAS#: 2310299-91-1 (citrate)
Chemical Formula: C20H27N5O11S
Exact Mass: 545.1428
Molecular Weight: 545.52
Elemental Analysis: C, 44.04; H, 4.99; N, 12.84; O, 32.26; S, 5.88

Price and Availability

Size Price Availability Quantity
50.0mg USD 250.0 2 Weeks
100.0mg USD 450.0 2 Weeks
200.0mg USD 750.0 2 Weeks
500.0mg USD 1350.0 2 Weeks
1.0g USD 2250.0 2 Weeks
5.0g USD 4250.0 2 Weeks
Bulk inquiry

Related CAS #: 2310299-91-1 (citrate)   1015787-98-0 (free base)    

Synonym: Gefapixant citrate; MK-7264; MK 7264; MK7264

IUPAC/Chemical Name: Benzenesulfonamide, 5-((2,4-diamino-5-pyrimidinyl)oxy)-2-methoxy-4-(1-methylethyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)


InChi Code: InChI=1S/C14H19N5O4S.C6H8O7/c1-7(2)8-4-10(22-3)12(24(17,20)21)5-9(8)23-11-6-18-14(16)19-13(11)15;7-3(8)1-6(13,5(11)12)2-4(9)10/h4-7H,1-3H3,(H2,17,20,21)(H4,15,16,18,19);13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

SMILES Code: COc1cc(C(C)C)c(Oc2cnc(N)nc2N)cc1S(=O)(=O)N.OC(=O)CC(O)(CC(=O)O)C(=O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 545.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

1. Morice AH, Kitt MM, Ford AP, Tershakovec AM, Wu WC, Brindle K, Thompson R, Thackray-Nocera S, Wright C. The effect of gefapixant, a P2X3 antagonist, on cough reflex sensitivity: a randomised placebo-controlled study. Eur Respir J. 2019 Jul 4;54(1):1900439. doi: 10.1183/13993003.00439-2019. PMID: 31023843.