GE-2270 A

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 575839

CAS#: 134861-34-0

Description: GE-2270 A inhibits bacterial protein synthesis in vitro via the GTP-bound form of elongation factor Tu.

Chemical Structure

GE-2270 A
CAS# 134861-34-0

Theoretical Analysis

MedKoo Cat#: 575839
Name: GE-2270 A
CAS#: 134861-34-0
Chemical Formula: C56H55N15O10S6
Exact Mass: 1,289.26
Molecular Weight: 1,290.510
Elemental Analysis: C, 52.12; H, 4.30; N, 16.28; O, 12.40; S, 14.91

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

Synonym: Antibiotic GE 2270A; GE 2270 A; GE2270 A; GE-2270 A; GE 2270; GE2270; GE-2270; MDL 62879; MDL62879; MDL-62879

IUPAC/Chemical Name: 9H,16H-8,5:15,12:22,19:32,29:36,33-Pentanitrilo-5H,29H,33H-pyrido(3,2-a1)(1,11,18,25,31,4,7,14,21)pentathiatetraazacyclotetratriacontine-18-acetamide, 2-(4-(4-((2-(aminocarbonyl)-1-pyrrolidinyl)carbonyl)-4,5-dihydro-2-oxazolyl)-2-thiazolyl)-10,11,17,18,23,24,25,26,27,28-decahydro-28-(hydroxyphenylmethyl)-14-(methoxymethyl)-N,21-dimethyl-11-(1-methylethyl)-9,16,23,26-tetraoxo-


InChi Code: InChI=1S/C56H55N15O10S6/c1-24(2)39-55-70-42(36(87-55)19-80-5)47(77)59-17-38(73)67-43(44(74)26-10-7-6-8-11-26)54-66-34(23-85-54)52-63-31(20-83-52)41-27(50-64-32(21-82-50)46(76)61-29(16-37(72)58-4)53-69-40(25(3)86-53)48(78)68-39)13-14-28(60-41)51-65-33(22-84-51)49-62-30(18-81-49)56(79)71-15-9-12-35(71)45(57)75/h6-8,10-11,13-14,20-24,29-30,35,39,43-44,74H,9,12,15-19H2,1-5H3,(H2,57,75)(H,58,72)(H,59,77)(H,61,76)(H,67,73)(H,68,78)/t29-,30-,35-,39-,43-,44-/m0/s1

SMILES Code: CNC(=O)C[C@@H]1NC(=O)c2csc(n2)c3ccc(nc3c4csc(n4)c5csc(n5)[C@@H](NC(=O)CNC(=O)c6nc(sc6COC)[C@@H](NC(=O)c7nc1sc7C)C(C)C)[C@@H](O)c8ccccc8)c9nc(cs9)C%10=N[C@@H](CO%10)C(=O)N%11CCC[C@H]%11C(=O)N

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:

Preparing Stock Solutions

The following data is based on the product molecular weight 1290.510000000000000000000000000000 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

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Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Heckmann G, Bach T. Synthesis of the heterocyclic core of the GE 2270 antibiotics and structure elucidation of a major degradation product. Angew Chem Int Ed Engl. 2005 Feb 11;44(8):1199-201. doi: 10.1002/anie.200461715. PMID: 15651011. 2. Prezioso SM, Brown NE, Goldberg JB. Elfamycins: inhibitors of elongation factor-Tu. Mol Microbiol. 2017 Oct;106(1):22-34. doi: 10.1111/mmi.13750. Epub 2017 Aug 9. PMID: 28710887; PMCID: PMC5701666.