WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 575812
Description: Ganciclovir monophosphonate is a synthetic analog of 2'-deoxy-guanosine which is used to treat or prevent cytomegalovirus (CMV) infections. It inhibits the replication of human CMV with an IC50 value of 0.01 μM and is effective against strains of CMV from human, monkey, mouse, and guinea pig.
MedKoo Cat#: 575812
Name: Ganciclovir monophosphonate
Chemical Formula: C10H16N5O6P
Exact Mass: 333.0838
Molecular Weight: 333.24
Elemental Analysis: C, 36.04; H, 4.84; N, 21.02; O, 28.81; P, 9.29
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: BW 2482U89; Ganciclovir monophosphonate; SR 3745
IUPAC/Chemical Name: Phosphonic acid, (3-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-4-hydroxybutyl)-, (R)-
InChi Key: QVNXYSKNFUJRMI-ZCFIWIBFSA-N
InChi Code: InChI=1S/C10H16N5O6P/c11-10-13-8-7(9(17)14-10)12-4-15(8)5-21-6(3-16)1-2-22(18,19)20/h4,6,16H,1-3,5H2,(H2,18,19,20)(H3,11,13,14,17)/t6-/m1/s1
SMILES Code: NC1=NC(=O)c2ncn(CO[C@@H](CO)CCP(=O)(O)O)c2N1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 333.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1. Balfour, H.H., Jr. Management of cytomegalovirus disease with antiviral drugs. Rev.Infect.Dis. 12(Suppl. 7), S849-S860 (1990).
2. Bean, B. Antiviral therapy: Current concepts and practices. Clin.Microbiol.Rev. 5(2), 146-182 (1992).
3. Rasmussen, L., Chen, P.T., Mullenax, J.G., et al. Inhibition of human cytomegalovirus replication by 9-(1,3-dihydroxy-2-propoxymethyl)guanine alone and in combination with human interferons. Antimicrob. Agents Chemother. 26(4), 441-445 (1984).
4. Freitas, V.R., Smee, D.F., Chernow, M., et al. Activity of 9-(1,3-dihydroxy-2-propoxymethyl)guanine compared with that of acyclovir against human, monkey, and rodent cytomegaloviruses. Antimicrob. Agents Chemother. 28(2), 240-245 (1985).