JNJ-pan-AR

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 463852

CAS#: unknown

Description: JNJ-pan-AR is a novel pan-AR antagonist with potent activity against wild-type and clinically relevant AR mutations including F877L.


Chemical Structure

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JNJ-pan-AR
CAS# unknown

Theoretical Analysis

MedKoo Cat#: 463852
Name: JNJ-pan-AR
CAS#: unknown
Chemical Formula: C25H24F3N5O2S
Exact Mass: 515.1603
Molecular Weight: 515.5552
Elemental Analysis: C, 58.24; H, 4.69; F, 11.06; N, 13.58; O, 6.21; S, 6.22

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: JNJ-pan-AR; JNJpan-AR; JNJ pan-AR; JNJ-pan AR; JNJ-panAR; JNJpanAR; JNJ pan AR;

IUPAC/Chemical Name: 5-(5-(4-((1-methylpiperidin-4-yl)oxy)phenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)picolinonitrile

InChi Key: IZKSMIBPGSWAMO-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H24F3N5O2S/c1-31-11-7-19(8-12-31)35-18-5-3-16(4-6-18)33-23(36)32(22(34)24(33)9-2-10-24)17-13-20(25(26,27)28)21(14-29)30-15-17/h3-6,13,15,19H,2,7-12H2,1H3

SMILES Code: N#CC1=NC=C(N(C2=O)C(N(C3=CC=C(OC4CCN(C)CC4)C=C3)C52CCC5)=S)C=C1C(F)(F)F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 515.5552 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Zhang Z, Connolly PJ, Lim HK, Pande V, Meerpoel L, Teleha C, Branch JR, Ondrus J, Hickson I, Bush T, Luistro L, Packman K, Bischoff JR, Ibrahim S, Parrett C, Chong Y, Gottardis MM, Bignan G. Discovery of JNJ-63576253: A Clinical Stage Androgen Receptor Antagonist for F877L Mutant and Wild-Type Castration-Resistant Prostate Cancer (mCRPC). J Med Chem. 2021 Jan 20. doi: 10.1021/acs.jmedchem.0c01563. Epub ahead of print. PMID: 33470111.

2: Hertzog JR, Zhang Z, Bignan G, Connolly PJ, Heindl JE, Janetopoulos CJ, Rupnow BA, McDevitt TM. AKR1C3 mediates pan-AR antagonist resistance in castration-resistant prostate cancer. Prostate. 2020 Oct;80(14):1223-1232. doi: 10.1002/pros.24049. Epub 2020 Jul 31. PMID: 33258507.