Eglin c (60-63)

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MedKoo CAT#: 463845

CAS#: 122299-14-3

Description: Eglin c (60-63) is a sequence of a peptide that has been studied for its inhibitory activity towards human leukocyte elastase, cathepsin G, porcine pancreatic elastase and alpha-chymotrypsin.

Chemical Structure

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Eglin c (60-63)
CAS# 122299-14-3
Instruction

Theoretical Analysis

MedKoo Cat#: 463845
Name: Eglin c (60-63)
CAS#: 122299-14-3
Chemical Formula: C18H33N5O7
Exact Mass: 431.24
Molecular Weight: 431.490
Elemental Analysis: C, 50.10; H, 7.71; N, 16.23; O, 25.95

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Eglin c (60-63); Eglin-c (60-63); Thr-asn-val-val-OH;

IUPAC/Chemical Name: L-threonyl-L-asparaginyl-L-valyl-L-valine

InChi Key: KAMOTFUFDACEHJ-ZZEGJQGJSA-N

InChi Code: InChI=1S/C18H33N5O7/c1-7(2)13(17(28)23-14(8(3)4)18(29)30)22-15(26)10(6-11(19)25)21-16(27)12(20)9(5)24/h7-10,12-14,24H,6,20H2,1-5H3,(H2,19,25)(H,21,27)(H,22,26)(H,23,28)(H,29,30)/t9-,10+,12+,13+,14+/m1/s1

SMILES Code: CC([C@@H](C(O)=O)NC([C@H](C(C)C)NC([C@@H](NC([C@H]([C@H](O)C)N)=O)CC(N)=O)=O)=O)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 431.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Tsuboi S, Takeda M, Okada Y, Nagamatsu Y, Yamamoto J. Amino acids and peptides. XXX. Synthesis of eglin c (41-49) and eglin c (60-63) and examination of their inhibitory activity towards human leukocyte elastase, cathepsin G, porcine pancreatic elastase and alpha-chymotrypsin. Chem Pharm Bull (Tokyo). 1991 Jan;39(1):184-6. doi: 10.1248/cpb.39.184. PMID: 2049802.

2: Tsuboi S, Nakabayashi K, Matsumoto Y, Teno N, Tsuda Y, Okada Y, Nagamatsu Y, Yamamoto J. Amino acids and peptides. XXVIII. Synthesis of peptide fragments related to eglin c and studies on the relationship between their structure and effects on human leukocyte elastase, cathepsin G and alpha-chymotrypsin. Chem Pharm Bull (Tokyo). 1990 Sep;38(9):2369-76. doi: 10.1248/cpb.38.2369. PMID: 2285973.