WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 463838
CAS#: 881001-19-0
Description: HDS-029 is a potent inhibitor of the ErbB receptor family. It inhibits EGF-induced erbB1 autophosphorylation in NIH3T3 cells and heregulin-stimulated ErbB autophosphorylation in MDA-MB-453 human breast carcinoma cells.
MedKoo Cat#: 463838
Name: HDS-029
CAS#: 881001-19-0
Chemical Formula: C17H11ClFN5O
Exact Mass: 355.0636
Molecular Weight: 355.7574
Elemental Analysis: C, 57.40; H, 3.12; Cl, 9.96; F, 5.34; N, 19.69; O, 4.50
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: HDS-029; HDS029; HDS 029; TKI-39; TKI39; TKI 39;
IUPAC/Chemical Name: N-(4-((3-chloro-4-fluorophenyl)amino)pyrido[3,4-d]pyrimidin-6-yl)but-2-ynamide
InChi Key: DLPSDPPZXRJQOY-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H11ClFN5O/c1-2-3-16(25)24-15-7-11-14(8-20-15)21-9-22-17(11)23-10-4-5-13(19)12(18)6-10/h4-9H,1H3,(H,20,24,25)(H,21,22,23)
SMILES Code: CC#CC(Nc(c1)ncc2c1c(Nc3cc(Cl)c(F)cc3)ncn2)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 355.7574 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
