HSPC

WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 414879

CAS#: 97281-48-6

Description: HSPC used in many FDA approved liposomal drug formulations, It is hydrogenated soybean phosphatidylcholine to improve the chemical and physical stability of the lipososmes prepared. It has been used in two important FDA approved liposomal drugs Doxil® and AmBisome®.

Chemical Structure

HSPC

CAS# 97281-48-6

Instruction

Theoretical Analysis

MedKoo Cat#: 414879
Name: HSPC
CAS#: 97281-48-6
Chemical Formula:
Exact Mass: 0.00
Molecular Weight: 0.000
Elemental Analysis:

Price and Availability

Size	Price	Availability	Quantity
200mg	USD 650	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: HSPC; L-α-phosphatidylcholine, hydrogenated (Soy); Hydro Soy PC;

IUPAC/Chemical Name: hydrogenated ≥99%L-α-Phosphatidylcholinefrom soybean (TLC) (HSPC)

InChi Key:

InChi Code:

SMILES Code:

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: [Sara Gaspani, Barbara Milani, Access to liposomal generic formulations: beyond AmBisome and Doxil/Caelyx. Generics and Biosimilars Initiative Journal (GaBI Journal). 2013;2(2):60-2. DOI: 10.5639/gabij.2013.0202.022]

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 0.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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1: Ding Y, Wang W, Ma D, Liang G, Kang Z, Xue Y, Zhang Y, Wang L, Heng J, Zhang Y, Liu F. Smarca5 mediated epigenetic programming facilitates fetal HSPC development in vertebrates. Blood. 2020 Aug 5:blood.2020005219. doi: 10.1182/blood.2020005219. Epub ahead of print. PMID: 32756943.

2: Carroll D, St Clair DK. Hematopoietic Stem Cells: Normal Versus Malignant. Antioxid Redox Signal. 2018 Dec 1;29(16):1612-1632. doi: 10.1089/ars.2017.7326. Epub 2017 Dec 20. PMID: 29084438; PMCID: PMC6207150.

3: Hess NJ, Lindner PN, Vazquez J, Grindel S, Hudson AW, Stanic AK, Ikeda A, Hematti P, Gumperz JE. Different Human Immune Lineage Compositions Are Generated in Non-Conditioned NBSGW Mice Depending on HSPC Source. Front Immunol. 2020 Oct 19;11:573406. doi: 10.3389/fimmu.2020.573406. PMID: 33193358; PMCID: PMC7604455.

4: Stewen J, Bixel MG. Intravital Imaging of Blood Flow and HSPC Homing in Bone Marrow Microvessels. Methods Mol Biol. 2019;2017:109-121. doi: 10.1007/978-1-4939-9574-5_9. PMID: 31197772.

5: Tedesco S, Ciciliot S, Menegazzo L, D'Anna M, Scattolini V, Cappellari R, Cignarella A, Avogaro A, Albiero M, Fadini GP. Pharmacologic PPAR-γ Activation Reprograms Bone Marrow Macrophages and Partially Rescues HSPC Mobilization in Human and Murine Diabetes. Diabetes. 2020 Jul;69(7):1562-1572. doi: 10.2337/db19-0640. Epub 2020 Apr 28. PMID: 32345753.

6: Liu M, Jin S, Yan H, Du S. Effect of oxymatrine HSPC liposomes on improving bioavailability, liver target distribution and hepatoprotective activity of oxymatrine. Eur J Pharm Sci. 2017 Jun 15;104:212-220. doi: 10.1016/j.ejps.2017.03.048. Epub 2017 Apr 5. PMID: 28389275.

7: Li D, Xue W, Li M, Dong M, Wang J, Wang X, Li X, Chen K, Zhang W, Wu S, Zhang Y, Gao L, Chen Y, Chen J, Zhou BO, Zhou Y, Yao X, Li L, Wu D, Pan W. VCAM-1+ macrophages guide the homing of HSPCs to a vascular niche. Nature. 2018 Dec;564(7734):119-124. doi: 10.1038/s41586-018-0709-7. Epub 2018 Nov 19. PMID: 30455424; PMCID: PMC6492262.

8: Shore ND. Darolutamide (ODM-201) for the treatment of prostate cancer. Expert Opin Pharmacother. 2017 Jun;18(9):945-952. doi: 10.1080/14656566.2017.1329820. Epub 2017 May 24. PMID: 28490267.

9: Hoyer FF, Zhang X, Coppin E, Vasamsetti SB, Modugu G, Schloss MJ, Rohde D, McAlpine CS, Iwamoto Y, Libby P, Naxerova K, Swirski FK, Dutta P, Nahrendorf M. Bone Marrow Endothelial Cells Regulate Myelopoiesis in Diabetes Mellitus. Circulation. 2020 Jul 21;142(3):244-258. doi: 10.1161/CIRCULATIONAHA.120.046038. Epub 2020 Apr 22. PMID: 32316750; PMCID: PMC7375017.

10: Dolstra H, Roeven MWH, Spanholtz J, Hangalapura BN, Tordoir M, Maas F, Leenders M, Bohme F, Kok N, Trilsbeek C, Paardekooper J, van der Waart AB, Westerweel PE, Snijders TJF, Cornelissen J, Bos G, Pruijt HFM, de Graaf AO, van der Reijden BA, Jansen JH, van der Meer A, Huls G, Cany J, Preijers F, Blijlevens NMA, Schaap NM. Successful Transfer of Umbilical Cord Blood CD34+ Hematopoietic Stem and Progenitor-derived NK Cells in Older Acute Myeloid Leukemia Patients. Clin Cancer Res. 2017 Aug 1;23(15):4107-4118. doi: 10.1158/1078-0432.CCR-16-2981. Epub 2017 Mar 9. PMID: 28280089.

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