JAK1-IN-38a

WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 463802

CAS#: unknown

Description: JAK1-IN-38a is a novel highly potent JAK1-selective inhibitor, exhibiting excellent selectivity over JAK2, JAK3, and TYK2.

Chemical Structure

JAK1-IN-38a

CAS# unknown

Handing Instruction

Theoretical Analysis

MedKoo Cat#: 463802
Name: JAK1-IN-38a
CAS#: unknown
Chemical Formula: C22H26ClN5O
Exact Mass: 411.1826
Molecular Weight: 411.934
Elemental Analysis: C, 64.15; H, 6.36; Cl, 8.61; N, 17.00; O, 3.88

Size	Price	Shipping out time	Quantity
Inquire bulk and customized quantity Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Pricing updated 2021-03-05. Prices are subject to change without notice.

JAK1-IN-38a is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, SDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Synonym: JAK1-IN-38a; JAK1IN-38a; JAK1 IN-38a; JAK1-IN38a; JAK1-IN 38a; JAK1IN38a; JAK1 IN 38a;

IUPAC/Chemical Name: 4-(((2S,4S)-1-(4-chlorobenzyl)-2-methylpiperidin-4-yl)amino)-N-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxamide

InChi Key: ZAVSMABHFLBCSH-YOEHRIQHSA-N

InChi Code: InChI=1S/C22H26ClN5O/c1-14-11-17(8-10-28(14)13-15-3-5-16(23)6-4-15)27-20-18-7-9-25-21(18)26-12-19(20)22(29)24-2/h3-7,9,12,14,17H,8,10-11,13H2,1-2H3,(H,24,29)(H2,25,26,27)/t14-,17-/m0/s1

SMILES Code: ClC1=CC=C(CN2CC[C@@H](C[C@@H]2C)NC3=C4C=CNC4=NC=C3C(NC)=O)C=C1

Appearance:

Solid powder

Purity:

>98% (or refer to the Certificate of Analysis)

Shipping Condition:

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:

Soluble in DMSO

Shelf Life:

>2 years if stored properly

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

2934.99.9001

Handling Instructions:

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 411.934 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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1: Park E, Lee SJ, Moon H, Park J, Jeon H, Hwang JS, Hwang H, Hong KB, Han SH, Choi S, Kang S. Discovery and Biological Evaluation of N-Methyl- pyrrolo[2,3-b]pyridine-5-carboxamide Derivatives as JAK1-Selective Inhibitors. J Med Chem. 2021 Jan 11. doi: 10.1021/acs.jmedchem.0c01026. Epub ahead of print. PMID: 33428419.

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