WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 463802
Description: JAK1-IN-38a is a novel highly potent JAK1-selective inhibitor, exhibiting excellent selectivity over JAK2, JAK3, and TYK2.
MedKoo Cat#: 463802
Chemical Formula: C22H26ClN5O
Exact Mass: 411.1826
Molecular Weight: 411.934
Elemental Analysis: C, 64.15; H, 6.36; Cl, 8.61; N, 17.00; O, 3.88
JAK1-IN-38a is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, SDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to email@example.com to inquire quote.
Synonym: JAK1-IN-38a; JAK1IN-38a; JAK1 IN-38a; JAK1-IN38a; JAK1-IN 38a; JAK1IN38a; JAK1 IN 38a;
IUPAC/Chemical Name: 4-(((2S,4S)-1-(4-chlorobenzyl)-2-methylpiperidin-4-yl)amino)-N-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
InChi Key: ZAVSMABHFLBCSH-YOEHRIQHSA-N
InChi Code: InChI=1S/C22H26ClN5O/c1-14-11-17(8-10-28(14)13-15-3-5-16(23)6-4-15)27-20-18-7-9-25-21(18)26-12-19(20)22(29)24-2/h3-7,9,12,14,17H,8,10-11,13H2,1-2H3,(H,24,29)(H2,25,26,27)/t14-,17-/m0/s1
SMILES Code: ClC1=CC=C(CN2CC[C@@H](C[C@@H]2C)NC3=C4C=CNC4=NC=C3C(NC)=O)C=C1
The following data is based on the product molecular weight 411.934 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Park E, Lee SJ, Moon H, Park J, Jeon H, Hwang JS, Hwang H, Hong KB, Han SH, Choi S, Kang S. Discovery and Biological Evaluation of N-Methyl- pyrrolo[2,3-b]pyridine-5-carboxamide Derivatives as JAK1-Selective Inhibitors. J Med Chem. 2021 Jan 11. doi: 10.1021/acs.jmedchem.0c01026. Epub ahead of print. PMID: 33428419.