SRI-37330 HCl

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MedKoo CAT#: 463768

CAS#: 2322245-49-6 (HCl)

Description: SRI-37330 hydrochloride is a novel inhibitor of TXNIP expression, decreasing glucagon secretion and action and blocking hepatic glucose output, reversing obesity- and STZ-induced diabetes and hepatic steatosis.

Chemical Structure

SRI-37330 HCl
CAS# 2322245-49-6 (HCl)

Theoretical Analysis

MedKoo Cat#: 463768
Name: SRI-37330 HCl
CAS#: 2322245-49-6 (HCl)
Chemical Formula: C16H20ClF3N4O2S
Exact Mass: 424.0948
Molecular Weight: 424.8672
Elemental Analysis: C, 45.23; H, 4.75; Cl, 8.34; F, 13.41; N, 13.19; O, 7.53; S, 7.55

Price and Availability

Size Price Availability Quantity
1.0mg USD 80.0 Ready to ship
5.0mg USD 150.0 Ready to ship
10.0mg USD 250.0 Ready to ship
25.0mg USD 550.0 Ready to ship
50.0mg USD 950.0 Ready to ship
100.0mg USD 1650.0 Ready to ship
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Related CAS #: 2322245-49-6 (HCl)   2322245-42-9 (free base)    

Synonym: SRI-37330 hydrochloride; SRI37330 hydrochloride; SRI 37330 hydrochloride; SRI-37330 HCl; SRI37330 HCl; SRI 37330 HCl;

IUPAC/Chemical Name: N-((1-(6-(trifluoromethyl)quinazolin-4-yl)piperidin-3-yl)methyl)methanesulfonamide hydrochloride


InChi Code: InChI=1S/C16H19F3N4O2S.ClH/c1-26(24,25)22-8-11-3-2-6-23(9-11)15-13-7-12(16(17,18)19)4-5-14(13)20-10-21-15;/h4-5,7,10-11,22H,2-3,6,8-9H2,1H3;1H

SMILES Code: CS(=O)(NCC1CN(C2=C3C=C(C(F)(F)F)C=CC3=NC=N2)CCC1)=O.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 424.8672 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Thielen LA, Chen J, Jing G, Moukha-Chafiq O, Xu G, Jo S, Grayson TB, Lu B, Li P, Augelli-Szafran CE, Suto MJ, Kanke M, Sethupathy P, Kim JK, Shalev A. Identification of an Anti-diabetic, Orally Available Small Molecule that Regulates TXNIP Expression and Glucagon Action. Cell Metab. 2020 Sep 1;32(3):353-365.e8. doi: 10.1016/j.cmet.2020.07.002. Epub 2020 Jul 28. PMID: 32726606; PMCID: PMC7501995.