DEPC
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: ZY041101

CAS#: 51779-95-4

Description: DEPC, also known as DC22:1PC or SJN79954, is a phospholipid containing erucic acid at the sn-1 and sn-2 positions. DEPC is a useful reagent in drug formulation study. It has been used in the study of lipid membranes and to determine the effect of long-chain phospholipids on the secondary structure of human islet amyloid polypeptide (hIAPP).


Price and Availability

Size Price Shipping out time Quantity
25mg USD 69 2-3 Weeks
100mg USD 79 2-3 Weeks
500mg USD 297 2-3 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-01-22. Prices are subject to change without notice.

DEPC is in stock. This product is being supplied by our partner ZY Therapeutic, Inc.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: ZY041101
Name: DEPC
CAS#: 51779-95-4
Chemical Formula: C52H100NO8P
Exact Mass: 897.7187
Molecular Weight: 898.3448
Elemental Analysis: C, 69.52; H, 11.22; N, 1.56; O, 14.25; P, 3.45


Synonym: DEPC, 1,2-DEPC; DC22:1PC; DC22:1PC; PC(22:1/22:1); SJN79954; SJN-79954; SJN 79954;

IUPAC/Chemical Name: 1,2-Dierucoyl-sn-glycero-3-phosphocholine

InChi Key: SDEURMLKLAEUAY-JFSPZUDSSA-N

InChi Code: InChI=1S/C52H100NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-38-40-42-44-51(54)58-48-50(49-60-62(56,57)59-47-46-53(3,4)5)61-52(55)45-43-41-39-37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h20-23,50H,6-19,24-49H2,1-5H3/b22-20-,23-21-/t50-/m1/s1

SMILES Code: CCCCCCCC/C=C\CCCCCCCCCCCC(O[C@@H](COP([O-])(OCC[N+](C)(C)C)=O)COC(CCCCCCCCCCC/C=C\CCCCCCCC)=O)=O


Technical Data

Appearance:
liquid.

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in ethanol (up to 30mg/mL)

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Sun D, Peyear TA, Bennett WFD, Holcomb M, He S, Zhu F, Lightstone FC, Andersen OS, Ingólfsson HI. Assessing the Perturbing Effects of Drugs on Lipid Bilayers Using Gramicidin Channel-Based In Silico and In Vitro Assays. J Med Chem. 2020 Oct 22;63(20):11809-11818. doi: 10.1021/acs.jmedchem.0c00958. Epub 2020 Oct 1. PMID: 32945672; PMCID: PMC7586341.

2: Sun D, Peyear TA, Bennett WFD, Andersen OS, Lightstone FC, Ingólfsson HI. Molecular Mechanism for Gramicidin Dimerization and Dissociation in Bilayers of Different Thickness. Biophys J. 2019 Nov 19;117(10):1831-1844. doi: 10.1016/j.bpj.2019.09.044. Epub 2019 Oct 10. PMID: 31676135; PMCID: PMC7018991.

3: Lum K, Ingólfsson HI, Koeppe RE 2nd, Andersen OS. Exchange of Gramicidin between Lipid Bilayers: Implications for the Mechanism of Channel Formation. Biophys J. 2017 Oct 17;113(8):1757-1767. doi: 10.1016/j.bpj.2017.08.049. PMID: 29045870; PMCID: PMC5647621.

4: Su CJ, Wu SS, Jeng US, Lee MT, Su AC, Liao KF, Lin WY, Huang YS, Chen CY. Peptide-induced bilayer thinning structure of unilamellar vesicles and the related binding behavior as revealed by X-ray scattering. Biochim Biophys Acta. 2013 Feb;1828(2):528-34. doi: 10.1016/j.bbamem.2012.10.027. Epub 2012 Nov 1. PMID: 23123565.

5: Tristram-Nagle S, Chan R, Kooijman E, Uppamoochikkal P, Qiang W, Weliky DP, Nagle JF. HIV fusion peptide penetrates, disorders, and softens T-cell membrane mimics. J Mol Biol. 2010 Sep 10;402(1):139-53. doi: 10.1016/j.jmb.2010.07.026. Epub 2010 Jul 22. PMID: 20655315; PMCID: PMC2940274.

6: Sobko AA, Kotova EA, Antonenko YN, Zakharov SD, Cramer WA. Lipid dependence of the channel properties of a colicin E1-lipid toroidal pore. J Biol Chem. 2006 May 19;281(20):14408-16. doi: 10.1074/jbc.M513634200. Epub 2006 Mar 23. PMID: 16556601.

7: Word RC, Smejtek P. Partitioning of tetrachlorophenol into lipid bilayers and sarcoplasmic reticulum: effect of length of acyl chains, carbonyl group of lipids and biomembrane structure. J Membr Biol. 2005 Feb;203(3):127-42. doi: 10.1007/s00232-005-0737-8. PMID: 15986092.

8: Weber ME, Schlesinger PH, Gokel GW. Dynamic assessment of bilayer thickness by varying phospholipid and hydraphile synthetic channel chain lengths. J Am Chem Soc. 2005 Jan 19;127(2):636-42. doi: 10.1021/ja044936+. PMID: 15643888; PMCID: PMC2615579.

9: Fernandes F, Loura LM, Prieto M, Koehorst R, Spruijt RB, Hemminga MA. Dependence of M13 major coat protein oligomerization and lateral segregation on bilayer composition. Biophys J. 2003 Oct;85(4):2430-41. doi: 10.1016/S0006-3495(03)74666-9. PMID: 14507706; PMCID: PMC1303467.

10: Wulf J, Pohl WG. Calcium ion-flux across phosphatidylcholine membranes mediated by ionophore A23187. Biochim Biophys Acta. 1977 Mar 17;465(3):471-85. doi: 10.1016/0005-2736(77)90266-8. PMID: 13833.