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MedKoo CAT#: 555902
CAS#: 2314467-60-0 (HCl)
Description: OUN67600, is a Novel Transient Receptor Potential Vanilloid 4 (TRPV4) Agonist as Regulators of Chondrogenic Differentiation. OUN67600 was first reported by Atobe et al (compound 36 in J Med Chem. 2019 Feb 14;62(3):1468-1483). OUN67600 has CAS#2314467-60-0, no formal name. For the convenience of scientific communication, we named it as OUN67600 (combined from Inchi key plus CAS#) according to Hodoodo Chemical Nomenclature (https://hodoodo.com/hodoodo-chemical-nomenclature).
MedKoo Cat#: 555902
Name: OUN67600
CAS#: 2314467-60-0 (HCl)
Chemical Formula: C25H23ClF2N4O2
Exact Mass:
Molecular Weight: 484.9318
Elemental Analysis: C, 61.92; H, 4.78; Cl, 7.31; F, 7.84; N, 11.55; O, 6.60
Related CAS #: 2314467-60-0 (HCl) 2314467-59-7 (free base)
Synonym: OUN67600; OUN-67600; ; OUN 67600; TRPV4 Agonist;
IUPAC/Chemical Name: 4(3H)-Quinazolinone, 8-fluoro-3-[4-(4-fluorophenoxy)phenyl]-2-(4-methyl-1-piperazinyl)-, hydrochloride (1:1)
InChi Key: ONVDBGZQVBEFIO-UHFFFAOYSA-N
InChi Code: InChI=1S/C25H22F2N4O2.ClH/c1-29-13-15-30(16-14-29)25-28-23-21(3-2-4-22(23)27)24(32)31(25)18-7-11-20(12-8-18)33-19-9-5-17(26)6-10-19;/h2-12H,13-16H2,1H3;1H
SMILES Code: O=C1N(C2=CC=C(OC3=CC=C(F)C=C3)C=C2)C(N4CCN(C)CC4)=NC5=C1C=CC=C5F.[H]Cl
Atobe M, Nagami T, Muramatsu S, Ohno T, Kitagawa M, Suzuki H, Ishiguro M, Watanabe A, Kawanishi M. Discovery of Novel Transient Receptor Potential Vanilloid 4 (TRPV4) Agonists as Regulators of Chondrogenic Differentiation: Identification of Quinazolin-4(3 H)-ones and in Vivo Studies on a Surgically Induced Rat Model of Osteoarthritis. J Med Chem. 2019 Feb 14;62(3):1468-1483. doi: 10.1021/acs.jmedchem.8b01615. Epub 2019 Jan 28. PMID: 30629441.